Gene Symbol | APCDD1 |
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Entrez Gene | 147495 |
Alt Symbol | B7323, DRAPC1, FP7019, HHS, HTS, HYPT1 |
Species | Human |
Gene Type | protein-coding |
Description | adenomatosis polyposis coli down-regulated 1 |
Other Description | adenomatosis polyposis coli down-regulated 1 protein|hypoptrichosis simplex|protein APCDD1 |
Swissprots | B4DZT0 Q8J025 Q71M25 B4DUQ0 |
Accessions | CAF32599 EAX01585 EAX01586 Q8J025 AB056722 BAC15563 AB104887 BAC65165 AF461902 AAQ04816 AK300743 BAG62412 AK303076 BAG64192 AL110199 BC053324 AAH53324 XM_011525603 XP_011523905 NM_153000 NP_694545 |
Function | Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. {ECO:0000269|PubMed:12384519, ECO:0000269|PubMed:20393562}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:20393562}; Single-pass type I membrane protein {ECO:0000269|PubMed:20393562}. |
Tissue Specificity | Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level). {ECO:0000269|PubMed:12384519, ECO:0000269|PubMed:20393562}. |
APCDD1 CRISPR/Cas9 KO Plasmid (h) - sc-406666 from Santa Cruz Biotechnology
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APCDD1 HDR Plasmid (h) - sc-406666-HDR from Santa Cruz Biotechnology
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APCDD1 Double Nickase Plasmid (h) - sc-406666-NIC from Santa Cruz Biotechnology
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APCDD1 Double Nickase Plasmid (h2) - sc-406666-NIC-2 from Santa Cruz Biotechnology
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APCDD1 CRISPR Activation Plasmid (h) - sc-406666-ACT from Santa Cruz Biotechnology
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APCDD1 CRISPR Activation Plasmid (h2) - sc-406666-ACT-2 from Santa Cruz Biotechnology
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APCDD1 Lentiviral Activation Particles (h) - sc-406666-LAC from Santa Cruz Biotechnology
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APCDD1 Lentiviral Activation Particles (h2) - sc-406666-LAC-2 from Santa Cruz Biotechnology
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APCDD1 siRNA (h) - sc-72512 from Santa Cruz Biotechnology
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APCDD1 shRNA Plasmid (h) - sc-72512-SH from Santa Cruz Biotechnology
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APCDD1 shRNA (h) Lentiviral Particles - sc-72512-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN3312 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3312 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05655 from Sigma-Aldrich
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APCDD1 siRNA (Human) - CRJ5523 from Cohesion Biosciences
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APCDD1 - MBS8204117 from MyBioSource
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shRNA set against Human APCDD1 (NM_153000.4) - SHH238130 from Creative biogene
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Human APCDD1 siRNA - orb276024 from Biorbyt
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APCDD1 shRNA Plasmid (Human) - CHJ5523 from Cohesion Biosciences
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APCDD1 miRNA 3'UTR clone - MiUTR3H-09256 from Creative biogene
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