DNM1L
| Gene Symbol | DNM1L |
|---|---|
| Entrez Gene | 10059 |
| Alt Symbol | DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynamin 1-like |
| Other Description | Dnm1p/Vps1p-like protein|dynamin family member proline-rich carboxyl-terminal domain less|dynamin-1-like protein|dynamin-like protein 4|dynamin-like protein IV|dynamin-related protein 1 |
| Swissprots | Q59GN9 A8K4X9 Q7L6B3 B4DGC9 O60709 Q8TBT7 Q9Y5J2 O14541 O00429 J3KPI2 Q9BWM1 B4DSU8 |
| Accessions | EAW88519 EAW88520 EAW88521 EAW88522 EAW88523 EAW88524 EAW88525 EAW88526 EAW88527 O00429 AA236613 AB006965 BAA22193 AB209070 BAD92307 AF000430 AAC23724 AF061795 AAC35283 AF151685 AAD39541 AK123906 AK291094 BAF83783 AK293290 BAG56814 AK294533 BAG57740 AK298568 BAG60761 AK299926 BAG61760 AK302565 BAG63828 AK311606 BC024590 AAH24590 BC107763 AAI07764 BF725436 DC377686 DQ891544 ABM82470 DQ894732 ABM85658 XM_005253282 XP_005253339 XM_005253283 XP_005253340 XM_011520543 XP_011518845 XM_011520544 XP_011518846 NM_001278463 NP_001265392 NM_001278464 NP_001265393 NM_001278465 NP_001265394 NM_001278466 NP_001265395 NM_005690 NP_005681 NM_012062 NP_036192 NM_012063 NP_036193 |
| Function | Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulate |
| Subcellular Location | Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Note=Mainly cytosolic. Translocated to the mitochondrial membrane through O- GlcNAcylation and interaction with FIS1. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. Binds to phospholipid membranes. |
| Tissue Specificity | Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons. {ECO:0000269|PubMed:10749171, ECO:0000269|PubMed:9422767, ECO:0000269|PubMed:9570752, ECO:0000269|PubMed:9731200, ECO:0000269|PubMed:9786947}. |
| Top Pathways | TNF signaling pathway |
DRP1 CRISPR/Cas9 KO Plasmid (h) - sc-400459 from Santa Cruz Biotechnology
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DRP1 HDR Plasmid (h) - sc-400459-HDR from Santa Cruz Biotechnology
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DRP1 Double Nickase Plasmid (h) - sc-400459-NIC from Santa Cruz Biotechnology
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DRP1 Double Nickase Plasmid (h2) - sc-400459-NIC-2 from Santa Cruz Biotechnology
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DRP1 CRISPR Activation Plasmid (h) - sc-400459-ACT from Santa Cruz Biotechnology
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DRP1 CRISPR Activation Plasmid (h2) - sc-400459-ACT-2 from Santa Cruz Biotechnology
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DRP1 Lentiviral Activation Particles (h) - sc-400459-LAC from Santa Cruz Biotechnology
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DRP1 Lentiviral Activation Particles (h2) - sc-400459-LAC-2 from Santa Cruz Biotechnology
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DRP1 siRNA (h) - sc-43732 from Santa Cruz Biotechnology
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DRP1 shRNA Plasmid (h) - sc-43732-SH from Santa Cruz Biotechnology
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DRP1 shRNA (h) Lentiviral Particles - sc-43732-V from Santa Cruz Biotechnology
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DRP1 RNAi - H00010059-R02 from Novus Biologicals
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DRP1 RNAi - H00010059-R03 from Novus Biologicals
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MISSION® esiRNA - EHU081751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7399 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7399 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08186 from Sigma-Aldrich
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DNM1L siRNA (Human) - CRH6775 from Cohesion Biosciences
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DRP1 RNAi - H00010059-R01 from Novus Biologicals
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DNM1L - MBS8212206 from MyBioSource
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shRNA set against Human DNM1L (NM_005690.3) - SHH279925 from Creative biogene
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Human DNM1L siRNA - orb267277 from Biorbyt
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DNM1L shRNA Plasmid (Human) - CHH6775 from Cohesion Biosciences
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DNM1L miRNA 3'UTR clone - MiUTR4H-TG02814 from Creative biogene
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