ARHGEF4

Gene Symbol	ARHGEF4
Entrez Gene	50649
Alt Symbol	ASEF, ASEF1, GEF4, STM6
Species	Human
Gene Type	protein-coding
Description	Rho guanine nucleotide exchange factor (GEF) 4
Other Description	APC-stimulated guanine nucleotide exchange factor 1|rho guanine nucleotide exchange factor 4
Swissprots	Q9HDC6 Q9UPP0 Q9NR80
Accessions	AAX93134 AAY24311 EAW51269 EAW51270 EAW51271 Q9NR80 AB029035 BAA83064 AB042199 BAB11941 AF249745 AAF79955 AK127124 AL137289 CAB70681 BC036579 BC139742 AAI39743 BC160189 AAI60189 DQ424905 ABD83670 XM_005263681 XP_005263738 XM_005263682 XP_005263739 XM_005263685 XP_005263742 XM_005263687 XP_005263744 XM_005263688 XP_005263745 XM_005263689 XP_005263746 XM_011511274 XP_011509576 XM_011511275 XP_011509577 XM_011511276 XP_011509578 XM_011511277 XP_011509579 NM_015320 NP_056135 NM_032995 NP_127462
Function	Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}.
Subcellular Location	Isoform 3: Cytoplasm. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Associated with membrane ruffles. {ECO:0000305}.
Tissue Specificity	Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269|PubMed:10873612, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:19893577}.
Top Pathways	Regulation of actin cytoskeleton

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Asef (H-140) - sc-33218 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Asef (N-20) - sc-13275 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ARHGEF4 antibody - ab26064 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-ARHGEF4 antibody [ARHGEF-08] - ab178551 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ARHGEF-08

Anti-ARHGEF4 antibody [ARHGEF-08] (Phycoerythrin) - ab191103 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ARHGEF-08

Anti-ARHGEF4 antibody - C-terminal - ab138549 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 antibody - N-terminal - ab171006 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa573-599, AP) - LS-C232820 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa573-599, FITC) - LS-C232823 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa143-271, clone ARHGEF-08) - LS-C204345 from LifeSpan Bioscience Prices $265.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ARHGEF-08

Anti-ARHGEF4 Antibody (aa573-599, Biotin) - LS-C232822 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa573-599, APC) - LS-C232821 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa573-599, Azide-free, HRP) - LS-C249455 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa573-599, PE) - LS-C232824 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa572-599) - LS-C319586 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa573-599) - LS-C159112 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa51-100) - LS-C170304 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ARHGEF4 Antibody (aa2-14) - LS-C54531 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

ARHGEF4 Antibody - NB100-1316 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

ARHGEF4 Antibody - NBP1-88857 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ARHGEF4 Antibody - H00050649-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-ARHGEF4 antibody produced in goat - SAB2500104 from Sigma-Aldrich Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-ARHGEF4 antibody produced in rabbit - HPA018267 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ANTI-ARHGEF4(C-TERMINAL) antibody produced in rabbit - SAB1306873 from Sigma-Aldrich Prices $326.00 Sizes 40 tst Host Rabbit Clonality Polyclonal

ARHGEF4 Antibody (OAEE00022) - OAEE00022 from Aviva Systems Biology Prices $190.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone ARHGEF-08

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