| Gene Symbol |
ARHGEF4
|
| Entrez Gene |
50649
|
| Alt Symbol |
ASEF, ASEF1, GEF4, STM6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rho guanine nucleotide exchange factor (GEF) 4
|
| Other Description |
APC-stimulated guanine nucleotide exchange factor 1|rho guanine nucleotide exchange factor 4
|
| Swissprots |
Q9HDC6 Q9UPP0 Q9NR80
|
| Accessions |
AAX93134 AAY24311 EAW51269 EAW51270 EAW51271 Q9NR80 AB029035 BAA83064 AB042199 BAB11941 AF249745 AAF79955 AK127124 AL137289 CAB70681 BC036579 BC139742 AAI39743 BC160189 AAI60189 DQ424905 ABD83670 XM_005263681 XP_005263738 XM_005263682 XP_005263739 XM_005263685 XP_005263742 XM_005263687 XP_005263744 XM_005263688 XP_005263745 XM_005263689 XP_005263746 XM_011511274 XP_011509576 XM_011511275 XP_011509577 XM_011511276 XP_011509578 XM_011511277 XP_011509579 NM_015320 NP_056135 NM_032995 NP_127462
|
| Function |
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:12598901, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19893577}.
|
| Subcellular Location |
Isoform 3: Cytoplasm. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Associated with membrane ruffles. {ECO:0000305}.
|
| Tissue Specificity |
Expressed at high levels in the brain, skeletal muscle and testis and at low levels in the kidney, lung, small intestine, ovary and prostate. Expression is aberrantly enhanced in most colorectal tumors. {ECO:0000269|PubMed:10873612, ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:19893577}.
|
| Top Pathways |
Regulation of actin cytoskeleton
|