SMARCAD1

Gene Symbol SMARCAD1
Entrez Gene 56916
Alt Symbol ADERM, ETL1, HEL1
Species Human
Gene Type protein-coding
Description SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Other Description ATP-dependent helicase 1|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Swissprots Q05D56 Q96SX1 Q9H4L7 B7Z799 Q9H017 Q9ULU7 Q9H860 Q9NPU9
Accessions EAX06049 EAX06050 EAX06051 Q9H4L7 AB032948 BAA86436 AK023990 BAB14759 AK025302 AK027490 BAB55150 AK301668 BAH13535 AL359929 CAB95769 AL512768 CAC21685 AL704040 AY008271 AAG16639 BC017953 AAH17953 BC041800 BC045534 AAH45534 DA798320 DB207879 EU446826 ABZ92355 EU832178 ACE87528 EU832271 ACE86841 XR_938765 XR_938766 NM_001128429 NP_001121901 NM_001128430 NP_001121902 NM_001254949 NP_001241878 NM_020159 NP_064544 NR_045644
Function DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Subcellular Location Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double- strand breaks (DSBs) sites of DNA damage.
Tissue Specificity Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin, fibroblasts, keratinocytes and esophagus. {ECO:0000269|PubMed:11031099, ECO:0000269|PubMed:21820097}.
Top Pathways Signaling pathways regulating pluripotency of stem cells

SMARCAD1 Antibody - 12458 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using SMARCAD1 Antibody.

Smarcad1 (C-14) - sc-162232 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Smarcad1 (C-14): sc-162232. Western blot analysis of Smarcad1 expression in Jurkat (A), K-562 (B) and U-251-MG (C) whole cell lysates.

Smarcad1 (N-16) - sc-162233 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Smarcad1 (N-16): sc-162233. Western blot analysis of Smarcad1 expression in HeLa (A), NIH/3T3 (B) and Hep G2 (C) nuclear extracts.

Anti-SMARCAD1 antibody - ab67548 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SMARCAD1 antibody (ab67548) at 1/500 dilutionLane 1 : SMARCAD1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-SMARCAD1 Antibody - LS-C334336 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using SMARCAD1 antibody. Blue: DAPI for nuclear staining.

Anti-SMARCAD1 Antibody (aa1-50) - LS-C288382 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCAD1 Antibody (aa976-1026) - LS-C288385 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCAD1 Antibody (aa51-100) - LS-C80097 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal heart lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-SMARCAD1 Antibody - LS-C341907 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMARCAD1 Antibody (aa218-267) - LS-C80099 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

SMARCAD1 Antibody - NBP1-85023 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMARCAD1 Antibody - H00056916-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SMARCAD1 Antibody [H00056916-B01P] - Analysis of SMARCAD1 expression in transfected 293T cell line by SMARCAD1 polyclonal antibody. Lane 1: SMARCAD1 transfected lysate(113.08 KDa). Lane 2: Non-transfected lysate.

SMARCAD1 Antibody - NB100-79835 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SMARCAD1 Antibody [NB100-79835] - Detection of Human and Mouse SMARCAD1/ETL1 on HeLa whole cell lysate using NB100-79835. SMARCAD1/ETL1 was also IPed by rabbit anti- SMARCAD1/ETL1 antibody NB100-79834.

SMARCAD1 Antibody - NB100-79834 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: SMARCAD1 Antibody [NB100-79834] - Detection of Human SMARCAD1/ETL1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SMARCAD1/ETL1 antibody NB100-79834 used for IP at 3 mcg/mg lysate. SMARCAD1/ETL1 was also immunoprecipitated by rabbit anti-SMARCAD1/ETL1 antibody NB10-79835, which recognizes a downstream epitope. Detection: Chemiluminescence with an exposure time of 3 seconds

SMARCAD1 Antibody - H00056916-D01 from Novus Biologicals

Prices $399.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMARCAD1 (AB1) antibody produced in rabbit - AV34592 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV34592</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type HepG2

Anti-SMARCAD1 antibody produced in rabbit - HPA016737 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SMARCAD1: <B>Cat. No. HPA016737</B>: Immunohistochemical staining of human small intestine shows strong nuclear positivity in glandular cells.

Anti-SMARCAD1 (AB2) antibody produced in rabbit - AV34529 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: fetal heart (<B>Cat. No. AV34529</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type fetal heart

Anti-SMARCAD1 antibody produced in mouse - SAB1407755 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SMARCAD1: <B>Cat. No. SAB1407755</B>: Antibody concentration: 10 μg/mL using HeLa cell.

SMARCAD1 antibody - N-terminal region (ARP34529_P050) - ARP34529_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMARCAD1 antibody - N-terminal region (ARP34592_P050) - ARP34592_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SMARCAD1-antibody-N-terminal-region - AI10135 from Abgent, a WuXi AppTec company

Prices $293.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SMARCAD1 antibody - N-terminal region (AI10135) in Human Heart cells using Western BlotWB Suggested Anti-SMARCAD1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:12500 Positive Control: Human heart

SMARCAD1 Polyclonal Antibody - A5850 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SMARCAD1 antibody.

SMARCAD1 Antibody - abx004487 from Abbexa

Host Rabbit
Clonality Polyclonal

SMARCAD1 antibody - H00056916-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Immunofluorescence of purified MaxPab antibody to SMARCAD1 on HeLa cell. [antibody concentration 10 ug/ml]
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