SMARCAD1

Gene Symbol	SMARCAD1
Entrez Gene	56916
Alt Symbol	ADERM, ETL1, HEL1
Species	Human
Gene Type	protein-coding
Description	SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Other Description	ATP-dependent helicase 1|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Swissprots	Q05D56 Q96SX1 Q9H4L7 B7Z799 Q9H017 Q9ULU7 Q9H860 Q9NPU9
Accessions	EAX06049 EAX06050 EAX06051 Q9H4L7 AB032948 BAA86436 AK023990 BAB14759 AK025302 AK027490 BAB55150 AK301668 BAH13535 AL359929 CAB95769 AL512768 CAC21685 AL704040 AY008271 AAG16639 BC017953 AAH17953 BC041800 BC045534 AAH45534 DA798320 DB207879 EU446826 ABZ92355 EU832178 ACE87528 EU832271 ACE86841 XR_938765 XR_938766 NM_001128429 NP_001121901 NM_001128430 NP_001121902 NM_001254949 NP_001241878 NM_020159 NP_064544 NR_045644
Function	DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000269|PubMed:21549307, ECO:0000269|PubMed:22960744}.
Subcellular Location	Nucleus. Chromosome. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double- strand breaks (DSBs) sites of DNA damage.
Tissue Specificity	Isoform 1 is expressed ubiquitously. Isoform 3 is expressed mainly in skin, fibroblasts, keratinocytes and esophagus. {ECO:0000269|PubMed:11031099, ECO:0000269|PubMed:21820097}.
Top Pathways	Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMARCAD1 full length protein - ab153429 from Abcam Category Protein Source Wheat germ Species Human

SMARCAD1 Antibody Blocking Peptide - LS-E12289 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SMARCAD1 Protein - H00056916-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SMARCAD1 - H00056916-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMARCAD1 - H00056916-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMARCAD1 fusion protein - ag4951 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SMARCAD1 fusion protein - Ag5281 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of - CSB-YP875675HU CSB-EP875675HU CSB-BP875675HU CSB-MP875675HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SMARCAD1 (transcript variant 3) - TP308438 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

SMARCAD1 Recombinant Protein Antigen - NBP1-85023PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SMARCAD1 Peptide, Human - M34GP14726H from Creative Peptides Category Peptide Source Synthetic. Species Human

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1), partial, Recombinant Protein - MBS1403591 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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