Gene Symbol | TFB2M |
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Entrez Gene | 64216 |
Alt Symbol | Hkp1, mtTFB2 |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor B2, mitochondrial |
Other Description | HCV NS5A-transactivated protein 5|S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2|dimethyladenosine transferase 2, mitochondrial|h-mtTFB|h-mtTFB2|hTFB2M|hepatitis C virus NS5A-transactivated protein 5|mitochondrial 12S rRNA dimethylase 2|mitochondrial transcription factor B2 |
Swissprots | Q9H626 Q9H5Q4 |
Accessions | EAW77149 EAW77150 EAW77151 EAW77152 EAW77153 Q9H5Q4 AF529366 AAQ09600 AK026314 BAB15441 AK026835 BAB15566 AK300238 BAG62006 BC003383 AAH03383 CK725134 DA038232 EU446518 ABZ92047 XM_011544248 XP_011542550 NM_022366 NP_071761 |
Function | S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. {ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:15526033, ECO:0000269|PubMed:20410300}. |
Subcellular Location | Mitochondrion. |
Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:12068295}. |
Human TFB2M full length protein - ab134620 from Abcam
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Human TFB2M peptide - ab23228 from Abcam
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TFB2M Antibody Blocking Peptide - LS-E73 from LifeSpan Bioscience
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TFB2M Antibody Blocking Peptide - LS-E27689 from LifeSpan Bioscience
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TFB2M Antibody Blocking Peptide - LS-E27688 from LifeSpan Bioscience
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TFB2M Antibody Blocking Peptide - LS-E12223 from LifeSpan Bioscience
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TFB2M Antibody Blocking Peptide - LS-E25434 from LifeSpan Bioscience
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TFB2M Antibody Blocking Peptide - LS-E14310 from LifeSpan Bioscience
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TFB2M Antibody Blocking Peptide - LS-E14309 from LifeSpan Bioscience
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TFB2M Partial Recombinant Protein - H00064216-Q01 from Novus Biologicals
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TFB2M Recombinant Protein - H00064216-P01 from Novus Biologicals
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Recombinant Human TFB2M Protein - NBP2-22878 from Novus Biologicals
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TFB2M-Antibody-C-term-Blocking-peptide - BP10145b from Abgent, a WuXi AppTec company
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TFB2M blocking peptide - GTX13676-PEP from GeneTex
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Human TFB2M protein - orb169415 from Biorbyt
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TFB2M protein (His tag) - 80R-2525 from Fitzgerald
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TFB2M Peptide - AC21-0262-P from Abcore
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TFB2M Peptide - AC21-2504-P from Abcore
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TFB2M (20-396, His-tag) - AR50597PU-N from Acris Antibodies
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TFB2M (20-396, His-tag) - AR50597PU-S from Acris Antibodies
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TFB2M - H00064216-P01 from Acris Antibodies
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TFB2M - H00064216-P01-25 from Acris Antibodies
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TFB2M - H00064216-Q01-10 from Acris Antibodies
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TFB2M - H00064216-Q01-25 from Acris Antibodies
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TFB2M, 20-396aa, Human, His tag, E.coli - 01-P1773 from ARP American Research Products
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