| Gene Symbol |
ELF5
|
| Entrez Gene |
2001
|
| Alt Symbol |
ESE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
E74-like factor 5 (ets domain transcription factor)
|
| Other Description |
ETS-related transcription factor Elf-5|epithelium-restricted ESE-1-related Ets factor|epithelium-specific Ets transcription factor 2
|
| Swissprots |
A8K452 Q9UKW5 Q8N2K9 O95175 Q96QY3 A6XAE6 Q9UKW6
|
| Accessions |
CAF86494 EAW68168 EAW68169 Q9UKW6 AF049703 AAC79755 AF115402 AAD22960 AF115403 AAD22961 AK074633 BAC11101 AK075197 BAG52081 AK290808 BAF83497 AK290817 BAF83506 AK312537 BAG35436 BC029743 AAH29743 BG260616 BP358543 DA630849 DQ123839 AAZ98848 DQ891137 ABM82063 DQ894316 ABM85242 NM_001243080 NP_001230009 NM_001243081 NP_001230010 NM_001422 NP_001413 NM_198381 NP_938195
|
| Function |
Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation. {ECO:0000269|PubMed:10506207}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00237}.
|
| Tissue Specificity |
Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression. {ECO:0000269|PubMed:10506207, ECO:0000269|PubMed:9840936}.
|
| Top Pathways |
Prolactin signaling pathway
|
