Gene Symbol | INPP5A |
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Entrez Gene | 3632 |
Alt Symbol | 5PTASE |
Species | Human |
Gene Type | protein-coding |
Description | inositol polyphosphate-5-phosphatase, 40kDa |
Other Description | 43 kDa inositol polyphosphate 5-phophatase|CTCL tumor antigen HD-CL-02|InsP3 5-phosphatase|inositol polyphosphate-5-phosphatase, 40kD|inositol trisphosphate-5-phosphatase, 40kD|type I inositol 1,4,5-trisphosphate 5-phosphatase|type I inositol-1,4,5-trisphosphate 5-phophatase|type I inositol-1,4,5-trisphosphate 5-phosphatase |
Swissprots | Q14642 Q14640 Q5JSF1 D3DXI3 |
Accessions | AAK13252 EAW61306 EAW61307 Q14642 AF273055 AAM44458 BC052265 AAH52265 BC062300 AAH62300 BC096280 AAH96280 BC096281 AAH96281 BC117515 AAI17516 BM467443 BM666428 CB960907 X77567 CAA54676 Z31695 CAA83500 XM_011539768 XP_011538070 XR_945735 NM_005539 NP_005530 |
Function | Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction. |
Subcellular Location | Membrane; Lipid-anchor. |
Tissue Specificity | Brain; high level in Purkinje cells. |
Top Pathways | Inositol phosphate metabolism, Phosphatidylinositol signaling system |
Type I 5-phosphatase CRISPR/Cas9 KO Plasmid (h) - sc-410836 from Santa Cruz Biotechnology
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Type I 5-phosphatase HDR Plasmid (h) - sc-410836-HDR from Santa Cruz Biotechnology
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Type I 5-phosphatase Double Nickase Plasmid (h) - sc-410836-NIC from Santa Cruz Biotechnology
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Type I 5-phosphatase Double Nickase Plasmid (h2) - sc-410836-NIC-2 from Santa Cruz Biotechnology
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Type I 5-phosphatase CRISPR Activation Plasmid (h) - sc-410836-ACT from Santa Cruz Biotechnology
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Type I 5-phosphatase CRISPR Activation Plasmid (h2) - sc-410836-ACT-2 from Santa Cruz Biotechnology
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Type I 5-phosphatase Lentiviral Activation Particles (h) - sc-410836-LAC from Santa Cruz Biotechnology
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Type I 5-phosphatase Lentiviral Activation Particles (h2) - sc-410836-LAC-2 from Santa Cruz Biotechnology
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Type I 5-phosphatase siRNA (h) - sc-39095 from Santa Cruz Biotechnology
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Type I 5-phoshatase shRNA Plasmid (h) - sc-39095-SH from Santa Cruz Biotechnology
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Type I 5-phoshatase shRNA (h) Lentiviral Particles - sc-39095-V from Santa Cruz Biotechnology
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INPP5A RNAi - H00003632-R01 from Novus Biologicals
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MISSION® esiRNA - EHU062261 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0269 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0268 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0270 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10691 from Sigma-Aldrich
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INPP5A siRNA (Human) - CRH2435 from Cohesion Biosciences
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INPP5A - MBS8202023 from MyBioSource
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shRNA set against Human Inpp5a (NM_005539.3) - SHH319697 from Creative biogene
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INPP5A shRNA Plasmid (Human) - CHH2435 from Cohesion Biosciences
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INPP5A miRNA 3'UTR clone - MiUTR1H-04954 from Creative biogene
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