| Gene Symbol |
GAPDH
|
| Entrez Gene |
374193
|
| Alt Symbol |
KNC-NDS6
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
glyceraldehyde-3-phosphate dehydrogenase
|
| Other Description |
peptidyl-cysteine S-nitrosylase GAPDH
|
| Swissprots |
Q90848 Q98926 Q90849 P00356
|
| Accessions |
AAA48774 P00356 AF047874 AAD02474 AY466166 BX934060 J00850 K01458 AAA48778 V00406 CAA23697 V00407 CAA23698 X01578 CAA25733 NM_204305 NP_989636
|
| Function |
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Biosynthesis of amino acids, Carbon metabolism
|