CLCA2

Gene Symbol CLCA2
Entrez Gene 9635
Alt Symbol CACC, CACC3, CLCRG2, CaCC-3
Species Human
Gene Type protein-coding
Description chloride channel accessory 2
Other Description CLCA family member 2, chloride channel regulator|calcium-activated chloride channel family member 2|calcium-activated chloride channel protein 3|calcium-activated chloride channel regulator 2|calcium-activated chloride channel-2|chloride channel regulator 2|chloride channel, calcium activated, family member 2|hCLCA2|hCaCC-3
Swissprots Q9Y6N2 A8K2T3 Q9UQC9
Accessions AAF21968 CAJ46930 CBX36868 CBY79740 CBY79759 CBY79778 CBY88734 CBY88762 CBY88781 CCA61670 CCA61689 CCA61708 CCA64035 CCA64156 CCA64175 CCA65385 CCA65416 CCD32745 EAW73187 Q9UQC9 AB026833 BAA77810 AF043977 AAD40367 AF127980 AAD48397 AK290348 BAF83037 AK296719 BAG59308 AK307937 BC041096 AAH41096 BE062109 XM_011542448 XP_011540750 NM_006536 NP_006527
Function Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.
Subcellular Location Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.
Tissue Specificity Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules. {ECO:0000269|PubMed:10362588, ECO:0000269|PubMed:10437792, ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11262615, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:14966209, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.
Top Pathways Olfactory transduction, Pancreatic secretion

CLCA2 (C-18) - sc-50556 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLCA2 (C-18): sc-50556. Western blot analysis of CLCA2 expression in HeLa (A), HUV-EC-C (B), MCF7 (C) and MDA-MB-231 (D) whole cell lysates.

CLCA2/5 (H-60) - sc-99223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CLCA2/5 (M-60) - sc-99224 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CLCA2/5 (T-19) - sc-50559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLCA2/5 (T-19): sc-50559. Western blot analysis of CLCA2/5 expression in mouse skin tissue extract.

Anti-CLCA2 antibody - ab108101 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CLCA2 antibody (ab108101) at 1 µg/ml + THP-1 cell lysate at 10 µg

Anti-CLCA2 antibody - ab56634 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56634 CLCA2 antibody at 1ug/ml.

Anti-CLCA2 Antibody (aa300-400) - LS-C306966 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CLCA2 Antibody (aa674-723) - LS-C117095 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CLCA2 antibody LS-C117095 Western blot of THP-1 cell lysate.

CLCA2 Antibody - NBP2-33482 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: CLCA2 Antibody [NBP2-33482] - Immunofluorescent staining of human cell line HaCaT shows localization to nucleus & cell junctions.

CLCA2 Antibody - NBP1-80071 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CLCA2 Antibody [NBP1-80071] - THP-1 cell lysate, concentration 0.2-1 ug/ml.

CLCA2 Antibody - H00009635-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

CLCA2 Antibody (1B9) - H00009635-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B9

Anti-CLCA2 antibody produced in rabbit - HPA047192 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CLCA2: <B>Cat. No. HPA047192</B>: Immunohistochemical staining of Human esophagus shows strong cytoplasmic and membranous positivity in squamous epithelial cells.

Monoclonal Anti-CLCA2 antibody produced in mouse - SAB1404746 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1D5
<B>Immunoblotting</B><BR/>Monoclonal Anti-CLCA2: <B>Cat. No. SAB1404746</B>: Antibody concentration: 1 μg/mL. Specific band of ~79.9 kDa using immunogen protein lysate.

Anti-CLCA2 (721-735) antibody produced in rabbit - C3996 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-CLCA2 (721-735): <B>Cat. No. C3996</B>: Immunofluorescence of HUVEC cells using CLCA2 (721-735) (RB),<B>Cat. No. C3996</B> (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

CLCA2 antibody - C-terminal region (ARP35195_P050) - ARP35195_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CLCA2-Antibody-monoclonal-M01 - AT1549a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B9
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.85 KDa) .

CLCA2 antibody - 70R-8069 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

CLCA2 antibody - 70R-16439 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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