| Gene Symbol |
CLCA2
|
| Entrez Gene |
9635
|
| Alt Symbol |
CACC, CACC3, CLCRG2, CaCC-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chloride channel accessory 2
|
| Other Description |
CLCA family member 2, chloride channel regulator|calcium-activated chloride channel family member 2|calcium-activated chloride channel protein 3|calcium-activated chloride channel regulator 2|calcium-activated chloride channel-2|chloride channel regulator 2|chloride channel, calcium activated, family member 2|hCLCA2|hCaCC-3
|
| Swissprots |
Q9Y6N2 A8K2T3 Q9UQC9
|
| Accessions |
AAF21968 CAJ46930 CBX36868 CBY79740 CBY79759 CBY79778 CBY88734 CBY88762 CBY88781 CCA61670 CCA61689 CCA61708 CCA64035 CCA64156 CCA64175 CCA65385 CCA65416 CCD32745 EAW73187 Q9UQC9 AB026833 BAA77810 AF043977 AAD40367 AF127980 AAD48397 AK290348 BAF83037 AK296719 BAG59308 AK307937 BC041096 AAH41096 BE062109 XM_011542448 XP_011540750 NM_006536 NP_006527
|
| Function |
Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.
|
| Tissue Specificity |
Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules. {ECO:0000269|PubMed:10362588, ECO:0000269|PubMed:10437792, ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11262615, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:14966209, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.
|
| Top Pathways |
Olfactory transduction, Pancreatic secretion
|
