| Gene Symbol |
CDC42EP3
|
| Entrez Gene |
10602
|
| Alt Symbol |
BORG2, CEP3, UB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CDC42 effector protein (Rho GTPase binding) 3
|
| Other Description |
CRIB-containing BORG2 protein|MSE55-related Cdc42-binding protein|MSE55-related protein|binder of Rho GTPases 2|cdc42 effector protein 3
|
| Swissprots |
Q9UQJ0 B2R8S0 O95353 Q9UKI2
|
| Accessions |
AAX93072 EAX00390 Q9UKI2 AF094521 AAC71773 AF104857 AAD16888 AF164118 AAD48815 AK055915 AK128735 BAG54721 AK313483 BAG36267 AL136842 CAB66776 AL538577 AL567387 AM393660 CAL38536 BC019270 AAH19270 BQ067953 BQ432066 BT007190 AAP35854 DB121680 HY003915 HY017509 XM_011532482 XP_011530784 NM_001270436 NP_001257365 NM_001270437 NP_001257366 NM_001270438 NP_001257367 NM_006449 NP_006440
|
| Function |
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}.
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:11035016}; Peripheral membrane protein {ECO:0000269|PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11035016}.
|
| Tissue Specificity |
Highly expressed in the heart and weakly in the brain. {ECO:0000269|PubMed:10490598}.
|
![Western Blot: CDC42EP3 Overexpression Lysate (Adult Normal) [NBL1-09009] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CDC42EP3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8854_CDC42EP3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09009-img0002.jpg)