Gene Symbol | CDC42EP3 |
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Entrez Gene | 10602 |
Alt Symbol | BORG2, CEP3, UB1 |
Species | Human |
Gene Type | protein-coding |
Description | CDC42 effector protein (Rho GTPase binding) 3 |
Other Description | CRIB-containing BORG2 protein|MSE55-related Cdc42-binding protein|MSE55-related protein|binder of Rho GTPases 2|cdc42 effector protein 3 |
Swissprots | Q9UQJ0 B2R8S0 O95353 Q9UKI2 |
Accessions | AAX93072 EAX00390 Q9UKI2 AF094521 AAC71773 AF104857 AAD16888 AF164118 AAD48815 AK055915 AK128735 BAG54721 AK313483 BAG36267 AL136842 CAB66776 AL538577 AL567387 AM393660 CAL38536 BC019270 AAH19270 BQ067953 BQ432066 BT007190 AAP35854 DB121680 HY003915 HY017509 XM_011532482 XP_011530784 NM_001270436 NP_001257365 NM_001270437 NP_001257366 NM_001270438 NP_001257367 NM_006449 NP_006440 |
Function | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269|PubMed:10490598, ECO:0000269|PubMed:11035016}. |
Subcellular Location | Endomembrane system {ECO:0000269|PubMed:11035016}; Peripheral membrane protein {ECO:0000269|PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11035016}. |
Tissue Specificity | Highly expressed in the heart and weakly in the brain. {ECO:0000269|PubMed:10490598}. |
Cdc42EP3 CRISPR/Cas9 KO Plasmid (h) - sc-411489 from Santa Cruz Biotechnology
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Cdc42EP3 HDR Plasmid (h) - sc-411489-HDR from Santa Cruz Biotechnology
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Cdc42EP3 Double Nickase Plasmid (h) - sc-411489-NIC from Santa Cruz Biotechnology
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Cdc42EP3 Double Nickase Plasmid (h2) - sc-411489-NIC-2 from Santa Cruz Biotechnology
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Cdc42EP3 CRISPR Activation Plasmid (h) - sc-411489-ACT from Santa Cruz Biotechnology
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Cdc42EP3 CRISPR Activation Plasmid (h2) - sc-411489-ACT-2 from Santa Cruz Biotechnology
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Cdc42EP3 Lentiviral Activation Particles (h) - sc-411489-LAC from Santa Cruz Biotechnology
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Cdc42EP3 Lentiviral Activation Particles (h2) - sc-411489-LAC-2 from Santa Cruz Biotechnology
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Cdc42EP3 siRNA (h) - sc-94418 from Santa Cruz Biotechnology
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Cdc42EP3 shRNA Plasmid (h) - sc-94418-SH from Santa Cruz Biotechnology
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Cdc42EP3 shRNA (h) Lentiviral Particles - sc-94418-V from Santa Cruz Biotechnology
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CDC42EP3 RNAi - H00010602-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN5788 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5788 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11224 from Sigma-Aldrich
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CDC42EP3 siRNA (Human) - CRH7216 from Cohesion Biosciences
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CDC42EP3 - MBS8203641 from MyBioSource
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shRNA set against Human CDC42EP3 (NM_006449.4) - SHH259881 from Creative biogene
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Human CDC42EP3 siRNA - orb267718 from Biorbyt
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CDC42EP3 shRNA Plasmid (Human) - CHH7216 from Cohesion Biosciences
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CDC42EP3 miRNA 3'UTR clone - MiUTR4H-TG01905 from Creative biogene
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