Cidea

Gene Symbol	Cidea
Entrez Gene	12683
Alt Symbol	AW212747
Species	Mouse
Gene Type	protein-coding
Description	cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
Other Description	cell death activator CIDE-A|cell death-inducing DFFA-like effector A
Swissprots	Q4V9X2 O70302
Accessions	ABO38174 EDL09649 EDL09650 O70302 AF041376 AAC34985 BB614324 BC096649 AAH96649 BQ554476 BQ554477 NM_007702 NP_031728
Function	Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. {ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22144693, ECO:0000269|PubMed:22245780, ECO:0000269|PubMed:9564035}.
Subcellular Location	Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Using a GFP-tagged construct, has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (PubMed:12910269). These data could not be confirmed (PubMed:22245780, PubMed:18509062). {ECO:0000269|PubMed:12910269, ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22245780}.
Tissue Specificity	Highly expressed in brown adipose tissue and, at lower levels, in white adipose tissue (at protein level). Expressed in mammary gland during pregnancy and lactation, in epithelial cells, but not in the surrounding adipose tissue. Secreted into milk via milk fat globules. Undetectable in undifferentiated preadipocytes. {ECO:0000269|PubMed:12910269, ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22245780}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

CIDE-A (M-20) - sc-8732 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CIDE A antibody - ab8402 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDEA Antibody - NBP1-76950 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CIDE-A, C-Terminal antibody produced in rabbit - C7977 from Sigma-Aldrich Prices $364.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CIDE-A (ab1) antibody produced in rabbit - PRS2089 from Sigma-Aldrich Prices $347.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Cell Death-Inducing Dffa-Like Effector A Antibody - abx111521 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 200 μl, 10 μl, 50 μl, 100 μl Host Rabbit Clonality Polyclonal

CIDEA Antibody - abx104146 from Abbexa Prices $490.00, $490.00, $490.00, $490.00 Sizes 10 μl, 50 μl, 100 μl, 200 μl Host Rabbit Clonality Polyclonal

CIDE-A (C-term) antibody - AP30230PU-N from Acris Antibodies Prices $340.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDE-A antibody - PAB11960 from Acris Antibodies Prices $500.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDE-A Antibody - 253331 from ABBIOTEC Prices $341.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDE-A Antibody - 24054 from Signalway Antibody Prices $390.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CIDE-A , Polyclonal Antibody - MBS221604 from MyBioSource Prices $350.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDE-A , Polyclonal Antibody - MBS223194 from MyBioSource Prices $275.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CIDEA (aa 200-214) polyclonal antibody - CPBT-66403RM from Creative Diagnostics Host Rabbit Clonality Polyclonal

Anti-CIDEA (aa 200-214) polyclonal antibody - DPAB-L20299 from Creative Diagnostics Host Rabbit Clonality Polyclonal

CIDEA Polyclonal Antibody - PA1-30117 from Thermo Fisher Scientific Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDEA Polyclonal Antibody - PA5-19908 from Thermo Fisher Scientific Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDE-A Antibody - 600-401-AK4 from Rockland Immunochemicals Inc Prices $319.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CIDE-A Antibody - ABC350 from EMD Millipore Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDE-A Antibody - AHP541 from AbD Serotec Prices $234.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CIDEA Antibody - CSB-PA005431GA01HU from Cusabio Host Rabbit

Cidea Antibody (OASA08378) - OASA08378 from Aviva Systems Biology Prices $360.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Cidea Antibody (OASA08379) - OASA08379 from Aviva Systems Biology Prices $265.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

anti-CIDE-A antibody - ARG54337 from Arigo Biolaboratories

CIDE-A, Polyclonal Antibody - MBS9403712 from MyBioSource Prices $320.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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