| Gene Symbol |
Cidea
|
| Entrez Gene |
12683
|
| Alt Symbol |
AW212747
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cell death-inducing DNA fragmentation factor, alpha subunit-like effector A
|
| Other Description |
cell death activator CIDE-A|cell death-inducing DFFA-like effector A
|
| Swissprots |
Q4V9X2 O70302
|
| Accessions |
ABO38174 EDL09649 EDL09650 O70302 AF041376 AAC34985 BB614324 BC096649 AAH96649 BQ554476 BQ554477 NM_007702 NP_031728
|
| Function |
Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. {ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22144693, ECO:0000269|PubMed:22245780, ECO:0000269|PubMed:9564035}.
|
| Subcellular Location |
Lipid droplet. Nucleus. Note=Enriched at lipid droplet contact sites. Using a GFP-tagged construct, has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (PubMed:12910269). These data could not be confirmed (PubMed:22245780, PubMed:18509062). {ECO:0000269|PubMed:12910269, ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22245780}.
|
| Tissue Specificity |
Highly expressed in brown adipose tissue and, at lower levels, in white adipose tissue (at protein level). Expressed in mammary gland during pregnancy and lactation, in epithelial cells, but not in the surrounding adipose tissue. Secreted into milk via milk fat globules. Undetectable in undifferentiated preadipocytes. {ECO:0000269|PubMed:12910269, ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22245780}.
|