| Gene Symbol |
CASR
|
| Entrez Gene |
846
|
| Alt Symbol |
CAR, EIG8, FHH, FIH, GPRC2A, HHC, HHC1, HYPOC1, NSHPT, PCAR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium-sensing receptor
|
| Other Description |
extracellular calcium-sensing receptor|parathyroid Ca(2+)-sensing receptor 1|parathyroid cell calcium-sensing receptor 1
|
| Swissprots |
Q16379 Q16109 Q4PJ19 Q13912 Q16108 P41180 Q16110 Q2M1T0
|
| Accessions |
AAB29413 AAB29414 AAB29415 AAP20759 AAY68221 ABD04091 ABD04092 ABD04093 ABD04094 ABD04095 ABD04096 ABK33660 ABK33661 ABK33662 ABK33663 CAA56990 CAV33589 CCV20013 CCW28005 EAW79490 EAW79491 EAW79492 P41180 BC104999 AAI05000 BC112236 AAI12237 BP388878 D50855 BAA09453 FJ360896 ACJ04039 S79217 AAB35262 S81755 AAD14370 S83176 AAB46873 U20759 AAA86503 U20760 AAA86504 W56898 XM_005247836 XP_005247893 XM_005247837 XP_005247894 XM_006713789 XP_006713852 XM_011513237 XP_011511539 XM_011513238 XP_011511540 XM_011513239 XP_011511541 NM_000388 NP_000379 NM_001178065 NP_001171536
|
| Function |
Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20861236}; Multi-pass membrane protein {ECO:0000269|PubMed:20861236}.
|
| Tissue Specificity |
Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta. {ECO:0000269|PubMed:18756473}.
|