| Gene Symbol |
B3gat3
|
| Entrez Gene |
100689419
|
| Alt Symbol |
GlcUAT-I, Glcat-i
|
| Species |
Hamster
|
| Gene Type |
protein-coding
|
| Description |
beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
|
| Other Description |
UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3|glucuronosyltransferase I
|
| Swissprots |
Q9WU47
|
| Accessions |
Q9WU47 AF113703 AAD22007 JI891796 NM_001246684 NP_001233613
|
| Function |
Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Highest activity seen with Gal-beta-1,3-Gal-beta-O-R (where R=naphthalenemethanol or benzyl alcohol). Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation. {ECO:0000250|UniProtKB:O94766}.
|
| Subcellular Location |
Golgi apparatus membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Liver, brain and heart. Moderate expression seen in lung, skeletal muscle, kidney and testis.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|