| Gene Symbol | B3gat3 |
|---|---|
| Entrez Gene | 100689419 |
| Alt Symbol | GlcUAT-I, Glcat-i |
| Species | Hamster |
| Gene Type | protein-coding |
| Description | beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) |
| Other Description | UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3|glucuronosyltransferase I |
| Swissprots | Q9WU47 |
| Accessions | Q9WU47 AF113703 AAD22007 JI891796 NM_001246684 NP_001233613 |
| Function | Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Highest activity seen with Gal-beta-1,3-Gal-beta-O-R (where R=naphthalenemethanol or benzyl alcohol). Stimulates 2-phosphoxylose phosphatase activity of PXYLP1 in presence of uridine diphosphate-glucuronic acid (UDP-GlcUA) during completion of linkage region formation. {ECO:0000250|UniProtKB:O94766}. |
| Subcellular Location | Golgi apparatus membrane; Single-pass type II membrane protein. |
| Tissue Specificity | Liver, brain and heart. Moderate expression seen in lung, skeletal muscle, kidney and testis. |
| Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin, Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
Recombinant Cricetulus griseus Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3(B3GAT3) - CSB-YP895281DXU CSB-EP895281DXU CSB-BP895281DXU CSB-MP895281DXU from Cusabio
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Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3), Recombinant Protein - MBS1429809 from MyBioSource
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