| Gene Symbol | EXOSC9 |
|---|---|
| Entrez Gene | 5393 |
| Alt Symbol | PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | exosome component 9 |
| Other Description | P75 polymyositis-scleroderma overlap syndrome associated autoantigen|P75 polymyositis-scleroderma overlap syndrome-associated autoantigen|PMSCL autoantigen, 75kD|autoantigen PM/Scl 1|exosome complex component RRP45|exosome complex exonuclease RRP45|polymyositis/scleroderma autoantigen 1, 75kDa |
| Swissprots | Q12883 Q86Y48 Q4W5P5 Q86Y41 Q06265 |
| Accessions | AAY40968 EAX05247 EAX05248 EAX05249 EAX05250 EAX05251 EAX05252 Q06265 AJ505989 CAD44530 AJ517294 CAD56889 AK301967 BAG63380 AK307548 AK310894 BC012371 BC140038 AAI40039 BC140039 AAI40040 BC142978 AAI42979 BU615347 BX649106 M58460 AAA58384 U09215 AAA18832 XM_011532035 XP_011530337 NM_001034194 NP_001029366 NM_005033 NP_005024 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Isoform 2: Nucleus, nucleolus. |
| Top Pathways | RNA degradation |