Gene Symbol | LCOR |
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Entrez Gene | 84458 |
Alt Symbol | MLR2 |
Species | Human |
Gene Type | protein-coding |
Description | ligand dependent nuclear receptor corepressor |
Other Description | ligand-dependent corepressor|mblk1-related protein 2 |
Swissprots | D3DR47 Q8N3L6 Q86T33 Q96JN0 Q5VW16 Q86T32 Q7Z723 |
Accessions | EAW49962 EAW49963 EAW49964 EAW49965 EAW49966 Q96JN0 AB058698 BAB47424 AB072899 AK023248 AK095345 AL832044 CAD91160 AL832106 CAD91159 AL834245 CAD38921 BC053359 AAH53359 BC128542 AAI28543 DA507116 DA788606 HQ448101 ADQ32582 XM_006718033 XP_006718096 XM_006718034 XP_006718097 XM_011540277 XP_011538579 NM_001170765 NP_001164236 NM_001170766 NP_001164237 NM_032440 NP_115816 |
Function | May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269|PubMed:12535528}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00320, ECO:0000269|PubMed:12535528}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:12535528}. |
LCOR CRISPR/Cas9 KO Plasmid (h) - sc-408632 from Santa Cruz Biotechnology
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LCOR HDR Plasmid (h) - sc-408632-HDR from Santa Cruz Biotechnology
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LCOR Double Nickase Plasmid (h) - sc-408632-NIC from Santa Cruz Biotechnology
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LCOR Double Nickase Plasmid (h2) - sc-408632-NIC-2 from Santa Cruz Biotechnology
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LCOR CRISPR Activation Plasmid (h) - sc-408632-ACT from Santa Cruz Biotechnology
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LCOR CRISPR Activation Plasmid (h2) - sc-408632-ACT-2 from Santa Cruz Biotechnology
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LCOR Lentiviral Activation Particles (h) - sc-408632-LAC from Santa Cruz Biotechnology
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LCOR Lentiviral Activation Particles (h2) - sc-408632-LAC-2 from Santa Cruz Biotechnology
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LCOR siRNA (h) - sc-90371 from Santa Cruz Biotechnology
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LCOR shRNA Plasmid (h) - sc-90371-SH from Santa Cruz Biotechnology
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LCOR shRNA (h) Lentiviral Particles - sc-90371-V from Santa Cruz Biotechnology
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LCoR RNAi - H00084458-R01 from Novus Biologicals
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MISSION® esiRNA - EHU068471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11610 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11610 from Sigma-Aldrich
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LCOR siRNA (Human) - CRJ3487 from Cohesion Biosciences
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shRNA set against Human LCOR (NM_032440.3) - SHH329167 from Creative biogene
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Human LCOR siRNA - orb273988 from Biorbyt
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LCOR shRNA Plasmid (Human) - CHJ3487 from Cohesion Biosciences
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