| Gene Symbol |
MAVS
|
| Entrez Gene |
57506
|
| Alt Symbol |
CARDIF, IPS-1, IPS1, VISA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial antiviral signaling protein
|
| Other Description |
CARD adapter inducing interferon beta|CARD adaptor inducing IFN-beta|IFN-B promoter stimulator 1|interferon beta promoter stimulator protein 1|mitochondrial antiviral-signaling protein|putative NF-kappa-B-activating protein 031N|virus-induced signaling adaptor|virus-induced-signaling adapter
|
| Swissprots |
Q9H8D3 Q7Z434 B2BD33 F5H6C8 Q9H4Y1 Q2HWT5 Q9ULE9 Q9H1H3 B2BD34 A8K6X0 M1P2Z0 Q86VY7 Q5T7I6 Q3I0Y2
|
| Accessions |
CAH56821 EAX10481 EAX10482 Q7Z434 AB033097 BAA86585 AB097003 BAC77356 AB232371 BAE79738 AK023799 BAB14684 AK056260 AK092705 AK095370 AK123956 BAC85734 AK130992 BAC85473 AK291785 BAF84474 AK296897 BAG59455 AL390136 AL833736 BC000073 BC028962 BC040719 BC040930 BC044952 AAH44952 BC052583 BC062310 BC063593 BM834250 BX649084 DB219666 DQ167126 ABA54890 DQ174270 AAZ80417 DQ181928 ABA19229 EF467323 ABR24161 EF467324 ABR24162 EU832500 ACE87672 EU832581 ACE86983 KC415005 AGF94754 NM_001206491 NP_001193420 NM_020746 NP_065797 NR_037921
|
| Function |
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:
|
| Subcellular Location |
Mitochondrion outer membrane. Mitochondrion. Peroxisome.
|
| Tissue Specificity |
Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles, Influenza A
|