MAVS

Gene Symbol MAVS
Entrez Gene 57506
Alt Symbol CARDIF, IPS-1, IPS1, VISA
Species Human
Gene Type protein-coding
Description mitochondrial antiviral signaling protein
Other Description CARD adapter inducing interferon beta|CARD adaptor inducing IFN-beta|IFN-B promoter stimulator 1|interferon beta promoter stimulator protein 1|mitochondrial antiviral-signaling protein|putative NF-kappa-B-activating protein 031N|virus-induced signaling adaptor|virus-induced-signaling adapter
Swissprots Q9H8D3 Q7Z434 B2BD33 F5H6C8 Q9H4Y1 Q2HWT5 Q9ULE9 Q9H1H3 B2BD34 A8K6X0 M1P2Z0 Q86VY7 Q5T7I6 Q3I0Y2
Accessions CAH56821 EAX10481 EAX10482 Q7Z434 AB033097 BAA86585 AB097003 BAC77356 AB232371 BAE79738 AK023799 BAB14684 AK056260 AK092705 AK095370 AK123956 BAC85734 AK130992 BAC85473 AK291785 BAF84474 AK296897 BAG59455 AL390136 AL833736 BC000073 BC028962 BC040719 BC040930 BC044952 AAH44952 BC052583 BC062310 BC063593 BM834250 BX649084 DB219666 DQ167126 ABA54890 DQ174270 AAZ80417 DQ181928 ABA19229 EF467323 ABR24161 EF467324 ABR24162 EU832500 ACE87672 EU832581 ACE86983 KC415005 AGF94754 NM_001206491 NP_001193420 NM_020746 NP_065797 NR_037921
Function Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868, ECO:0000269|PubMed:16177806, ECO:0000269|PubMed:19631370, ECO:
Subcellular Location Mitochondrion outer membrane. Mitochondrion. Peroxisome.
Tissue Specificity Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:16125763, ECO:0000269|PubMed:16127453, ECO:0000269|PubMed:16153868}.
Top Pathways RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Hepatitis C, Measles, Influenza A

MAVS Antibody - 3993 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from LNCaP, MCF-7, and HT29 cell lines using MAVS Antibody.

MAVS Antibody (Rodent Specific) - 4983 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A20 and CTLL-2 cell lines using MAVS Antibody (Rodent Specific).

MAVS (E-3) - sc-166583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAVS (E-3): sc-166583. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

MAVS (H-135) - sc-68926 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MAVS (H-135): sc-68926. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing basal membrane staining of hepatocytes and cytoplasmic staining of Bile duct cells.

MAVS (T-20) - sc-70096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MAVS antibody - ab25084 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MAVS was immunoprecipitated using 0.5mg Jurkat whole cell extract, 5µg of Rabbit polyclonal to MAVS and 50µl of protein G magnetic beads (+). No antibody was added to the control (-). The antibody was incubated under agitation with Protein G beads for 10min, Jurkat whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70oC; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab25084.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 70kDa: MAVS

Anti-MAVS antibody - ab189109 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cortex tissue labelling MAVS with ab189109 at 5 µg/ml, followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-MAVS antibody - ab89825 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-MAVS antibody (ab89825) at 1 µg/ml + Human placenta tissue lysate at 50 µgdeveloped using the ECL technique

Anti-MAVS antibody - ab116545 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MAVS antibody (ab116545) at 1/100 dilution + HeLa cell line lysates at 35 µg

Anti-MAVS antibody - ab70825 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MAVS antibody - ChIP Grade - ab31334 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAVS antibody - ChIP Grade (ab31334) at 1 µg/mlLane 1 : Hela Whole Cell LysateLane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 3 : A431 (Human epithelial carcinoma cell line) Whole Cell Lysate (ab7909)Lysates/proteins at 20 µg per lane.SecondaryRabbit IgG secondary antibody (ab28446) at 1/10000 dilution

Anti-MAVS antibody - N-terminal - ab189303 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human thymus tissue, labeling MAVS with ab189303 at 5 µg/ml.

Anti-VISA / MAVS Antibody - LS-C18627 from LifeSpan Bioscience

Prices $420.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (C-Terminus) - LS-C72724 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody - LS-C121312 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (N-Terminus) - LS-C194039 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa477-505, AP) - LS-C262739 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa477-505, APC) - LS-C262740 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa477-505, Biotin) - LS-C262741 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa477-505, FITC) - LS-C262742 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa477-505, Azide-free, HRP) - LS-C262743 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa477-505, PE) - LS-C262744 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa1-30, AP) - LS-C262745 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-VISA / MAVS Antibody (aa470-519) - LS-C81406 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-VISA / MAVS Antibody (aa1-30, APC) - LS-C262746 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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