Gene Symbol | COL3A1 |
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Entrez Gene | 1281 |
Alt Symbol | EDS4A |
Species | Human |
Gene Type | protein-coding |
Description | collagen, type III, alpha 1 |
Other Description | Ehlers-Danlos syndrome type IV, autosomal dominant|alpha1 (III) collagen|collagen alpha-1(III) chain|collagen, fetal |
Swissprots | Q541P8 Q7KZ56 Q9UC91 Q6LDJ2 Q15112 P02461 Q9UC90 Q6LDB3 Q16403 Q6LDJ3 D2JYH5 D3DPH4 P78429 Q9UC89 V9GZI1 R4N3C5 Q8N6U4 Q9UC88 Q53S91 |
Accessions | AAA51999 AAA52000 AAA52001 AAA52002 AAA52040 AAA52041 AAD13937 AAL13167 AAY24164 ACZ58371 AGL34959 CDM55397 CDM55578 EAX10909 EAX10910 EAX10911 P02461 AI755052 AK091853 AK308010 BC028178 AAH28178 BP374999 M11134 AAA52004 M13146 AAA52003 M59227 AAB59383 S79877 AAB35615 X01655 CAA25821 X01742 CAA25878 X06700 CAA29886 X07240 CAA30229 X14420 CAA32583 X15332 CAA33387 NM_000090 NP_000081 |
Function | Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of GPR56 in the developing brain and binding to GPR56 inhibits neuronal migration and activates the RhoA pathway by coupling GPR56 to GNA13 and possibly GNA12. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}. |
Top Pathways | Focal adhesion, ECM-receptor interaction, Amoebiasis, Protein digestion and absorption, PI3K-Akt signaling pathway |
COL3A1 CRISPR/Cas9 KO Plasmid (h) - sc-400356 from Santa Cruz Biotechnology
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COL3A1 HDR Plasmid (h) - sc-400356-HDR from Santa Cruz Biotechnology
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COL3A1 Double Nickase Plasmid (h) - sc-400356-NIC from Santa Cruz Biotechnology
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COL3A1 Double Nickase Plasmid (h2) - sc-400356-NIC-2 from Santa Cruz Biotechnology
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COL3A1 CRISPR Activation Plasmid (h) - sc-400356-ACT from Santa Cruz Biotechnology
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COL3A1 CRISPR Activation Plasmid (h2) - sc-400356-ACT-2 from Santa Cruz Biotechnology
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COL3A1 Lentiviral Activation Particles (h) - sc-400356-LAC from Santa Cruz Biotechnology
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COL3A1 Lentiviral Activation Particles (h2) - sc-400356-LAC-2 from Santa Cruz Biotechnology
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COL3A1 siRNA (h) - sc-43062 from Santa Cruz Biotechnology
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COL3A1 shRNA Plasmid (h) - sc-43062-SH from Santa Cruz Biotechnology
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COL3A1 shRNA (h) Lentiviral Particles - sc-43062-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6388 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6388 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07623 from Sigma-Aldrich
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COL3A1 siRNA (Human) - CRH0896 from Cohesion Biosciences
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COL3A1 - MBS8200688 from MyBioSource
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shRNA set against Human COL3A1 (NM_000090.3) - SHH267249 from Creative biogene
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shRNA set against Human COL3A1(NM_000090.3) - SHG190315 from Creative biogene
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COL3A1 shRNA Plasmid (Human) - CHH0896 from Cohesion Biosciences
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COL3A1 miRNA 3'UTR clone - MiUTR1H-02320 from Creative biogene
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