| Gene Symbol |
NR0B1
|
| Entrez Gene |
190
|
| Alt Symbol |
AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 0, group B, member 1
|
| Other Description |
DSS-AHC critical region on the X chromosome protein 1|nuclear hormone receptor|nuclear receptor DAX-1|nuclear receptor subfamily 0 group B member 1
|
| Swissprots |
P51843 Q96F69
|
| Accessions |
AAC13875 AAD14311 EAW99051 P51843 AW612655 BC011564 AAH11564 BI772108 HQ692832 ADZ17343 S74720 AAB32751 NM_000475 NP_000466
|
| Function |
Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16709599}. Cytoplasm {ECO:0000269|PubMed:16709599}. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus.
|
![Western Blot: NR0B1 Overexpression Lysate (Adult Normal) [NBL1-13764] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NR0B1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7302_NR0B1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13764-img0002.jpg)