Gene Symbol | NR0B1 |
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Entrez Gene | 190 |
Alt Symbol | AHC, AHCH, AHX, DAX-1, DAX1, DSS, GTD, HHG, NROB1, SRXY2 |
Species | Human |
Gene Type | protein-coding |
Description | nuclear receptor subfamily 0, group B, member 1 |
Other Description | DSS-AHC critical region on the X chromosome protein 1|nuclear hormone receptor|nuclear receptor DAX-1|nuclear receptor subfamily 0 group B member 1 |
Swissprots | P51843 Q96F69 |
Accessions | AAC13875 AAD14311 EAW99051 P51843 AW612655 BC011564 AAH11564 BI772108 HQ692832 ADZ17343 S74720 AAB32751 NM_000475 NP_000466 |
Function | Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:16709599}. Cytoplasm {ECO:0000269|PubMed:16709599}. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus. |
DAX-1 CRISPR/Cas9 KO Plasmid (h) - sc-402180 from Santa Cruz Biotechnology
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DAX-1 HDR Plasmid (h) - sc-402180-HDR from Santa Cruz Biotechnology
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DAX-1 Double Nickase Plasmid (h) - sc-402180-NIC from Santa Cruz Biotechnology
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DAX-1 Double Nickase Plasmid (h2) - sc-402180-NIC-2 from Santa Cruz Biotechnology
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DAX-1 CRISPR Activation Plasmid (h) - sc-402180-ACT from Santa Cruz Biotechnology
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DAX-1 CRISPR Activation Plasmid (h2) - sc-402180-ACT-2 from Santa Cruz Biotechnology
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DAX-1 Lentiviral Activation Particles (h) - sc-402180-LAC from Santa Cruz Biotechnology
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DAX-1 Lentiviral Activation Particles (h2) - sc-402180-LAC-2 from Santa Cruz Biotechnology
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DAX-1 siRNA (h) - sc-35175 from Santa Cruz Biotechnology
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DAX-1 shRNA Plasmid (h) - sc-35175-SH from Santa Cruz Biotechnology
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DAX-1 shRNA (h) Lentiviral Particles - sc-35175-V from Santa Cruz Biotechnology
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DAX1/NR0B1 RNAi - H00000190-R01 from Novus Biologicals
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MISSION® esiRNA - EHU122111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1718 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1718 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00418 from Sigma-Aldrich
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NR0B1 siRNA (Human) - CRH0134 from Cohesion Biosciences
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shRNA set against Human NR0B1 (NM_000475.4) - SHH354612 from Creative biogene
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Human NR0B1 siRNA - orb260636 from Biorbyt
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NR0B1 shRNA Plasmid (Human) - CHH0134 from Cohesion Biosciences
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NR0B1 miRNA 3'UTR clone - MiUTR3H-02792 from Creative biogene
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