LIMA1

Gene Symbol	LIMA1
Entrez Gene	51474
Alt Symbol	EPLIN, SREBP3
Species	Human
Gene Type	protein-coding
Description	LIM domain and actin binding 1
Other Description	1110021C24Rik|LIM domain and actin-binding protein 1|epithelial protein lost in neoplasm beta|sterol regulatory element binding protein 3
Swissprots	B2RB09 Q59FE8 Q9P0H8 Q2TAN7 Q9NX96 Q9NXU6 Q9NXC3 Q9BVF2 Q9UHB6 Q9H8J1 Q9UHB5 Q9HBN5
Accessions	CCQ43539 EAW58134 EAW58135 EAW58136 Q9UHB6 AA772616 AB209512 BAD92749 AF157325 AAF67491 AF198454 AAF23755 AF198455 AAF23756 AF218025 AAG17267 AK000057 BAA90914 AK000335 BAA91092 AK000372 BAA91120 AK023649 BAB14625 AK096172 BAG53224 AK222971 BAD96691 AK297766 BAG60114 AK314447 BAG37056 AL136911 CAB66845 BC001247 AAH01247 BC010664 AAH10664 BC110815 AAI10816 BC136763 AAI36764 BC144402 BC144403 BP216703 BP281423 DA738195 XM_011538455 XP_011536757 NM_001113546 NP_001107018 NM_001113547 NP_001107019 NM_001243775 NP_001230704 NM_016357 NP_057441
Function	Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. {ECO:0000269|PubMed:12566430}.
Subcellular Location	Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein co- localizes with actin stress fibers and focal adhesion plaques.
Tissue Specificity	Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LIMA1 overexpression lysate - LY402544 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

LIMA1 overexpression lysate - LY426434 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

LIMA1 293 Cell Lysate - 402227 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

EPLIN Overexpression Lysate (Native) - NBL1-12533 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

EPLIN (h): 293 Lysate - sc-110636 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

LIMA1 Over-expression Lysate Product - GWB-8FC3C4 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

EPLIN Overexpression Lysate (Native) - NBP2-11412 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human LIMA1 Knockdown Stable Cell Line - CSC-DC008712 from Creative biogene Category Cell Line Species Human

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