LIMA1

Gene Symbol LIMA1
Entrez Gene 51474
Alt Symbol EPLIN, SREBP3
Species Human
Gene Type protein-coding
Description LIM domain and actin binding 1
Other Description 1110021C24Rik|LIM domain and actin-binding protein 1|epithelial protein lost in neoplasm beta|sterol regulatory element binding protein 3
Swissprots B2RB09 Q59FE8 Q9P0H8 Q2TAN7 Q9NX96 Q9NXU6 Q9NXC3 Q9BVF2 Q9UHB6 Q9H8J1 Q9UHB5 Q9HBN5
Accessions CCQ43539 EAW58134 EAW58135 EAW58136 Q9UHB6 AA772616 AB209512 BAD92749 AF157325 AAF67491 AF198454 AAF23755 AF198455 AAF23756 AF218025 AAG17267 AK000057 BAA90914 AK000335 BAA91092 AK000372 BAA91120 AK023649 BAB14625 AK096172 BAG53224 AK222971 BAD96691 AK297766 BAG60114 AK314447 BAG37056 AL136911 CAB66845 BC001247 AAH01247 BC010664 AAH10664 BC110815 AAI10816 BC136763 AAI36764 BC144402 BC144403 BP216703 BP281423 DA738195 XM_011538455 XP_011536757 NM_001113546 NP_001107018 NM_001113547 NP_001107019 NM_001243775 NP_001230704 NM_016357 NP_057441
Function Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. {ECO:0000269|PubMed:12566430}.
Subcellular Location Cytoplasm. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=This cytoskeletal protein co- localizes with actin stress fibers and focal adhesion plaques.
Tissue Specificity Highly expressed in placenta, kidney, pancreas, prostate, ovary, spleen and heart. Also detected in lung, liver, brain, skeletal muscle, thymus, testis and intestine. Not detected in leukocytes. Isoform Beta expressed generally at very low levels. Isoform Alpha abundant in epithelial cells from mammary gland, prostate and in normal oral keratinocytes. Low levels in aortic endothelial cells and dermal fibroblasts. Not detectable in myocardium.

EPLIN Antibody - 14043 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from MDA-MB-231 and MDA-MB-468 cells using EPLIN Antibody.

EPLIN (20) - sc-136399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EPLIN (20): sc-136399. Western blot analysis of EPLIN expression in HeLa whole cell lysate.

EPLIN (E-12) - sc-49945 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EPLIN (G-13) - sc-49946 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EPLIN (G-13): sc-49946. Western blot analysis of EPLIN expression in non-transfected: sc-117752 (A) and mouse EPLIN transfected: sc-120078 (B) 293T whole cell lysates.

EPLIN (X-23) - sc-133553 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
EPLIN (X-23): sc-133553. Western blot analysis of EPLIN expression in human placenta tissue extract.

Anti-EPLIN antibody - ab154530 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EPLIN antibody (ab154530) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-EPLIN antibody - ab130532 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-EPLIN antibody (ab130532) at 1/100 dilution + A549 cell line lysate at 35 µg

Anti-EPLIN Antibody (C-Terminus) - LS-C65482 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa500-550) - LS-C65483 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (clone 1B7) - LS-C134069 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B7

Anti-EPLIN Antibody (aa135-163, AP) - LS-C237122 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa135-163, FITC) - LS-C237123 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa502-551) - LS-C29994 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Placenta Lysate

Anti-EPLIN Antibody (aa135-163, APC) - LS-C237124 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa135-163, Biotin) - LS-C237125 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa135-163, PE) - LS-C237126 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa135-163, Azide-free, HRP) - LS-C248708 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa134-163) - LS-C322656 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-EPLIN Antibody (aa143-192) - LS-C109972 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
LIMA1 / EPLIN antibody LS-C109972 Western blot of Placenta lysate.

Anti-EPLIN Antibody (N-Terminus) IHC-plus™ - LS-B12141 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-EPLIN Antibody (aa135-163) - LS-C165774 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LIMA1 Antibody western blot of A549 cell line lysates (35 ug/lane). The LIMA1 antibody detected the LIMA1 protein (arrow).

Anti-EPLIN Antibody (aa500-550) - LS-C287141 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EPLIN by Immunoprecipitation. Samples: Whole cell lysate (500 ug) from DU145 cells. Antibodies: Affinity purified rabbit anti-EPLIN antibody used at 10 ug/mg lysate for IP. Affinity purified rabbit anti-EPLIN antibody was used at 1 ug/ml for WB. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-EPLIN Antibody (C-Terminus) IHC-plus™ - LS-B11278 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-EPLIN antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11278 concentration 5 ug/ml.

Anti-EPLIN Antibody (C-Terminus) IHC-plus™ - LS-B11882 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)

EPLIN Antibody - NB100-2305 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EPLIN Antibody [NB100-2305] - Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from MCF7 cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-EPLIN antibody (lot was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
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