Gene Symbol | PSME1 |
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Entrez Gene | 5720 |
Alt Symbol | IFI5111, PA28A, PA28alpha, REGalpha |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) |
Other Description | 11S regulator complex subunit alpha|29-kD MCP activator subunit|IGUP I-5111|activator of multicatalytic protease subunit 1|interferon gamma up-regulated I-5111 protein|interferon-gamma IEF SSP 5111|interferon-gamma-inducible protein 5111|proteasome activator complex subunit 1 |
Swissprots | A6NJG9 Q06323 H0YNE3 Q9UEF4 Q6IBM2 |
Accessions | AAA53230 AAF02217 BAA28836 EAW66105 EAW66106 Q06323 AI445328 AK307150 AK308572 AK311490 AK312211 BAG35144 BC000352 AAH00352 BC007503 AAH07503 BJ993879 BM470561 BM981616 BQ060125 BT019337 AAV38144 BU192084 BU731923 BX248293 CAD62621 CR456780 CAG33061 CR541658 CAG46459 DQ185047 DQ891838 ABM82764 DQ895024 ABM85950 L07633 AAA16521 NM_001281528 NP_001268457 NM_001281529 NP_001268458 NM_006263 NP_006254 NM_176783 NP_788955 |
Function | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
Top Pathways | Proteasome, Antigen processing and presentation |
PA28α CRISPR/Cas9 KO Plasmid (h) - sc-407623 from Santa Cruz Biotechnology
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PA28α HDR Plasmid (h) - sc-407623-HDR from Santa Cruz Biotechnology
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PA28α Double Nickase Plasmid (h) - sc-407623-NIC from Santa Cruz Biotechnology
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PA28α Double Nickase Plasmid (h2) - sc-407623-NIC-2 from Santa Cruz Biotechnology
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PA28α CRISPR Activation Plasmid (h) - sc-407623-ACT from Santa Cruz Biotechnology
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PA28α CRISPR Activation Plasmid (h2) - sc-407623-ACT-2 from Santa Cruz Biotechnology
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PA28α Lentiviral Activation Particles (h) - sc-407623-LAC from Santa Cruz Biotechnology
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PA28α Lentiviral Activation Particles (h2) - sc-407623-LAC-2 from Santa Cruz Biotechnology
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PA28α siRNA (h) - sc-106752 from Santa Cruz Biotechnology
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PA28α shRNA Plasmid (h) - sc-106752-SH from Santa Cruz Biotechnology
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PA28α shRNA (h) Lentiviral Particles - sc-106752-V from Santa Cruz Biotechnology
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PA28 Activator alpha Subunit/PSME1 RNAi - H00005720-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN17628 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17628 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01823 from Sigma-Aldrich
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PSME1 siRNA (Human) - CRH3865 from Cohesion Biosciences
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PA28 Activator alpha Subunit/PSME1 RNAi - H00005720-R02 from Novus Biologicals
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shRNA set against Human PSME1 (NM_176783.1) - SHH385516 from Creative biogene
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shRNA set against Human PSME1(NM_176783.1) - SHR149010 from Creative biogene
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shRNA set against Human PSME1(NM_006263.2) - SHR149028 from Creative biogene
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PSME1 shRNA Plasmid (Human) - CHH3865 from Cohesion Biosciences
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PSME1 miRNA 3'UTR clone - MiUTR1H-08393 from Creative biogene
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PSME1 miRNA 3'UTR clone - MiUTR1H-08394 from Creative biogene
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