| Gene Symbol |
TGFB1
|
| Entrez Gene |
100033900
|
| Alt Symbol |
-
|
| Species |
Horse
|
| Gene Type |
protein-coding
|
| Description |
transforming growth factor, beta 1
|
| Other Description |
TGF-beta-1|transforming growth factor beta 1|transforming growth factor beta-1
|
| Swissprots |
Q9TUM8 O19011
|
| Accessions |
O19011 AF175709 AAD49431 HM569606 ADK90115 X99438 CAA67801 XM_005596086 XP_005596143 NM_001081849 NP_001075318
|
| Function |
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T- helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. {ECO:0000250|UniProtKB:P04202}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Top Pathways |
Hippo signaling pathway, Tuberculosis, MAPK signaling pathway, Pancreatic cancer, Renal cell carcinoma
|