GOT1

Gene Symbol GOT1
Entrez Gene 2805
Alt Symbol ASTQTL1, GIG18, cAspAT, cCAT
Species Human
Gene Type protein-coding
Description glutamic-oxaloacetic transaminase 1, soluble
Other Description aspartate aminotransferase 1|aspartate aminotransferase, cytoplasmic|aspartate transaminase 1|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|glutamate oxaloacetate transaminase 1|growth-inhibiting protein 18|transaminase A
Swissprots Q5VW80 P17174 B7Z7E9 B2R6R7
Accessions AAC32851 CBF96059 CBV09579 EAW49868 EAW49869 P17174 AF052153 AAC28622 AK293483 BAH11518 AK301916 BAH13585 AK309174 AK312684 BAG35564 AY513279 AAT08032 BC000498 AAH00498 DA581933 EB387028 M37400 AAA35563 XR_945681 NM_002079 NP_002070
Function Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269|PubMed:16039064}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:1974457}.
Top Pathways Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Tyrosine metabolism, Biosynthesis of amino acids

AATC (V-14) - sc-46283 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AATC (V-14): sc-46283. Western blot analysis of AATC expression in Hep G2 (A), c4 (B) and TT (C) whole cell lysates and mouse liver tissue extract (D).

AATC (E-12) - sc-46281 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
AATC (E-12): sc-46281. Western blot analysis of AATC expression in non-transfected: sc-117752 (A) and mouse AATC transfected: sc-118148 (B) 293T whole cell lysates.

AATC (H-75) - sc-367196 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
AATC (H-75): sc-367196. Western blot analysis of AATC expression in Hep G2 (A), c4 (B), TT (C) and NCI-H226 (D) whole cell lysates and mouse liver tissue extract (E).

Anti-Aspartate Aminotransferase antibody - ab104265 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Aspartate Aminotransferase antibody (ab104265) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

Anti-Aspartate Aminotransferase antibody [EPR12145] - ab170950 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12145
Immunofluorescent analysis of HepG2 cells labeling Aspartate Aminotransferase using ab170950 at 1/50 dilution (green). DAPI nuclear staining (blue).

Anti-Aspartate Aminotransferase antibody [EPR12145] (Alexa Fluor® 647) - ab201043 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12145
ab201043 staining Aspartate Aminotransferase in MCF7 cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab201043 at 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at 2µg/ml (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-Aspartate Aminotransferase Antibody (aa1-413, Biotin) - LS-C298380 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa1-413, Biotin) - LS-C298381 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa1-413, Biotin) - LS-C298382 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa1-413, FITC) - LS-C302834 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (N-Terminus) - LS-C81182 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-Aspartate Aminotransferase Antibody (aa1-413, FITC) - LS-C302835 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa1-413, FITC) - LS-C302837 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody - LS-C306412 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody - LS-C309530 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa1-413) - LS-C294036 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant Aspartate Aminotransferase.

Anti-Aspartate Aminotransferase Antibody - LS-C309532 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa1-413) - LS-C292944 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant Aspartate Aminotransferase.

Anti-Aspartate Aminotransferase Antibody - LS-C314078 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa22-35) - LS-C54928 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.5 ug/ml) staining of Human Liver lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-Aspartate Aminotransferase Antibody - LS-C314722 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Guinea Pig
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (FITC) - LS-C316843 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (Biotin) - LS-C318752 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (HRP) - LS-C316844 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aspartate Aminotransferase Antibody (aa360-390) - LS-C321712 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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