GOT1

Gene Symbol	GOT1
Entrez Gene	2805
Alt Symbol	ASTQTL1, GIG18, cAspAT, cCAT
Species	Human
Gene Type	protein-coding
Description	glutamic-oxaloacetic transaminase 1, soluble
Other Description	aspartate aminotransferase 1|aspartate aminotransferase, cytoplasmic|aspartate transaminase 1|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|glutamate oxaloacetate transaminase 1|growth-inhibiting protein 18|transaminase A
Swissprots	Q5VW80 P17174 B7Z7E9 B2R6R7
Accessions	AAC32851 CBF96059 CBV09579 EAW49868 EAW49869 P17174 AF052153 AAC28622 AK293483 BAH11518 AK301916 BAH13585 AK309174 AK312684 BAG35564 AY513279 AAT08032 BC000498 AAH00498 DA581933 EB387028 M37400 AAA35563 XR_945681 NM_002079 NP_002070
Function	Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269|PubMed:16039064}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:1974457}.
Top Pathways	Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Tyrosine metabolism, Biosynthesis of amino acids

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GOT1-Over-expression-Lysate - LY10921a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GOT1 293T Cell Transient Overexpression Lysate(Denatured) - H00002805-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GOT1 overexpression lysate - LY400762 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

GOT1 293 Cell Lysate - 400731 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Aspartate Aminotransferase Overexpression Lysate (Denatured) - H00002805-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Aspartate Aminotransferase Overexpression Lysate (Native) - NBL1-11207 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

GOT1 Over-expression Lysate Product - GWB-28C67B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human GOT1 Knockdown Stable Cell Line - CSC-DC006461 from Creative biogene Category Cell Line Species Human

Human GOT1 Knockout Cell Line-HeLa - CSC-RT1686 from Creative biogene Category Cell Line Species Human

GOT1 KO Cell Lysate-HeLa - CLKO-1533 from Creative biogene Category Cell Lysate

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