| Gene Symbol | GOT1 |
|---|---|
| Entrez Gene | 2805 |
| Alt Symbol | ASTQTL1, GIG18, cAspAT, cCAT |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamic-oxaloacetic transaminase 1, soluble |
| Other Description | aspartate aminotransferase 1|aspartate aminotransferase, cytoplasmic|aspartate transaminase 1|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|glutamate oxaloacetate transaminase 1|growth-inhibiting protein 18|transaminase A |
| Swissprots | Q5VW80 P17174 B7Z7E9 B2R6R7 |
| Accessions | AAC32851 CBF96059 CBV09579 EAW49868 EAW49869 P17174 AF052153 AAC28622 AK293483 BAH11518 AK301916 BAH13585 AK309174 AK312684 BAG35564 AY513279 AAT08032 BC000498 AAH00498 DA581933 EB387028 M37400 AAA35563 XR_945681 NM_002079 NP_002070 |
| Function | Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000269|PubMed:16039064}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:1974457}. |
| Top Pathways | Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Tyrosine metabolism, Biosynthesis of amino acids |