SLC9A1
| Gene Symbol | SLC9A1 |
|---|---|
| Entrez Gene | 6548 |
| Alt Symbol | APNH, LIKNS, NHE-1, NHE1, PPP1R143 |
| Species | Human |
| Gene Type | protein-coding |
| Description | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 |
| Other Description | Na(+)/H(+) exchanger 1|Na-Li countertransporter|protein phosphatase 1, regulatory subunit 143|sodium/hydrogen exchanger 1|solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)|solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive) |
| Swissprots | B1ALD6 Q96EM2 P19634 D3DPL4 |
| Accessions | CBX47581 EAX07773 EAX07774 EAX07775 P19634 AF141350 AAF21350 AF141351 AAF21351 AF141352 AAF21352 AF141353 AAF21353 AF141354 AAF21354 AF141355 AAF21355 AF141356 AAF21356 AF141357 AAF21357 AF141358 AAF21358 AF141359 AAF21359 AF146430 AAF25592 AF146431 AAF25593 AF146432 AAF25594 AF146433 AAF25595 AF146434 AAF25596 AF146435 AAF25597 AF146436 AAF25598 AF146437 AAF25599 AF146438 AAF25600 AF146439 AAF25601 AK096921 AK124218 AK300432 BAG62158 AK314190 BAG36869 BC012121 AAH12121 BC030272 BC090942 BQ775239 BQ775318 DA313453 DA853045 JF432248 ADZ15465 M81768 AAB59460 M96066 M96067 S68616 AAC60606 XM_011542021 XP_011540323 NM_003047 NP_003038 NR_046474 |
| Function | Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}. |
| Subcellular Location | Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane. {ECO:0000250}. |
| Tissue Specificity | Kidney and intestine. |
| Top Pathways | Bile secretion, Pancreatic secretion, Gastric acid secretion, Adrenergic signaling in cardiomyocytes, Salivary secretion |
NHE-1 CRISPR/Cas9 KO Plasmid (h) - sc-400748 from Santa Cruz Biotechnology
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NHE-1 HDR Plasmid (h) - sc-400748-HDR from Santa Cruz Biotechnology
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NHE-1 Double Nickase Plasmid (h) - sc-400748-NIC from Santa Cruz Biotechnology
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NHE-1 Double Nickase Plasmid (h2) - sc-400748-NIC-2 from Santa Cruz Biotechnology
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NHE-1 CRISPR Activation Plasmid (h) - sc-400748-ACT from Santa Cruz Biotechnology
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NHE-1 CRISPR Activation Plasmid (h2) - sc-400748-ACT-2 from Santa Cruz Biotechnology
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NHE-1 Lentiviral Activation Particles (h) - sc-400748-LAC from Santa Cruz Biotechnology
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NHE-1 Lentiviral Activation Particles (h2) - sc-400748-LAC-2 from Santa Cruz Biotechnology
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NHE-1 siRNA (h) - sc-42650 from Santa Cruz Biotechnology
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NHE-1 shRNA Plasmid (h) - sc-42650-SH from Santa Cruz Biotechnology
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NHE-1 shRNA (h) Lentiviral Particles - sc-42650-V from Santa Cruz Biotechnology
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NHE1/SLC9A1 RNAi - H00006548-R01 from Novus Biologicals
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MISSION® esiRNA - EHU025551 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2133 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2133 from Sigma-Aldrich
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SLC9A1 siRNA (Human) - CRH4440 from Cohesion Biosciences
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SLC9A1 - MBS829823 from MyBioSource
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shRNA set against Human SLC9A1 (NM_003047.4) - SHH412256 from Creative biogene
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Human SLC9A1 siRNA - orb264942 from Biorbyt
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SLC9A1 shRNA Plasmid (Human) - CHH4440 from Cohesion Biosciences
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SLC9A1 miRNA 3'UTR clone - MiUTR3H-00161 from Creative biogene
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