SLC9A1

Gene Symbol SLC9A1
Entrez Gene 6548
Alt Symbol APNH, LIKNS, NHE-1, NHE1, PPP1R143
Species Human
Gene Type protein-coding
Description solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
Other Description Na(+)/H(+) exchanger 1|Na-Li countertransporter|protein phosphatase 1, regulatory subunit 143|sodium/hydrogen exchanger 1|solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)|solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive)
Swissprots B1ALD6 Q96EM2 P19634 D3DPL4
Accessions CBX47581 EAX07773 EAX07774 EAX07775 P19634 AF141350 AAF21350 AF141351 AAF21351 AF141352 AAF21352 AF141353 AAF21353 AF141354 AAF21354 AF141355 AAF21355 AF141356 AAF21356 AF141357 AAF21357 AF141358 AAF21358 AF141359 AAF21359 AF146430 AAF25592 AF146431 AAF25593 AF146432 AAF25594 AF146433 AAF25595 AF146434 AAF25596 AF146435 AAF25597 AF146436 AAF25598 AF146437 AAF25599 AF146438 AAF25600 AF146439 AAF25601 AK096921 AK124218 AK300432 BAG62158 AK314190 BAG36869 BC012121 AAH12121 BC030272 BC090942 BQ775239 BQ775318 DA313453 DA853045 JF432248 ADZ15465 M81768 AAB59460 M96066 M96067 S68616 AAC60606 XM_011542021 XP_011540323 NM_003047 NP_003038 NR_046474
Function Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. {ECO:0000269|PubMed:11350981, ECO:0000269|PubMed:15035633, ECO:0000269|PubMed:8901634}.
Subcellular Location Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with CHP1 at the reticulum endoplasmic (By similarity). Colocalizes with CHP1 and CHP2 at the plasma membrane. {ECO:0000250}.
Tissue Specificity Kidney and intestine.
Top Pathways Bile secretion, Pancreatic secretion, Gastric acid secretion, Adrenergic signaling in cardiomyocytes, Salivary secretion

NHE-1 (C-20) - sc-16097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NHE-1 (C-20): sc-16097. Western blot analysis of NHE-1expression in MOLT-4 (A), K-562 (B) and II-ACS (C) wholecell lysates.

NHE-1 (H-160) - sc-28758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NHE-1 (H-160): sc-28758. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing membrane and cytoplasmic staining of glandular cells.

NHE-1 (K-16) - sc-33325 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NHE-1 (K-16): sc-33325. Western blot analysis of NHE-1 expression in rat skeletal muscle tissue extract.

NHE-1 (T-20) - sc-16096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NHE-1 (T-20): sc-16096. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic staining of glandular cells.

NHE-1 (C-13) - sc-33326 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NHE-1 (C-13): sc-33326. Immunoperoxidase staining of formalin fixed, paraffin-embedded human small intestine tissue showing membrane and cytoplasmic staining of glandular cells.

NHE-1 (54) - sc-136239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
NHE-1 (54): sc-136239. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

NHE-1 (2Q2265) - sc-71696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
NHE-1 (2Q2265): sc-71696. Western blot analysis of NHE-1 expression in MOLT-4 (A), K-562 (B) and HeLa (C) whole cell lysates.

NHE-1 (4E9) - sc-58635 from Santa Cruz Biotechnology

Prices $295.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
NHE-1 (4E9): sc-58635. Western blot analysis of NHE-1 expression in MOLT-4 (A), K-562 (B) and HeLa (C) whole cell lysates.

Anti-Sodium / Hydrogen Exchanger 1 antibody - ab67314 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Sodium / Hydrogen Exchanger 1 antibody (ab67314) at 1 µg/mlLane 2 : Anti-Sodium / Hydrogen Exchanger 1 antibody (ab67314) at 2 µg/mlLane 1 : MOLT4 cell lysateLane 2 : MOLT4 cell lysateLysates/proteins at 15 µg per lane.

Anti-Sodium / Hydrogen Exchanger 1 antibody - ab67313 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Sodium / Hydrogen Exchanger 1 antibody (ab67313) at 1 µg/mlLane 2 : Anti-Sodium / Hydrogen Exchanger 1 antibody (ab67313) at 2 µg/mlLane 1 : Rat kidney tissue lysateLane 2 : Rat kidney tissue lysateLysates/proteins at 15 µg per lane.

Anti-Sodium / Hydrogen Exchanger 1 antibody - ab58304 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Sodium / Hydrogen Exchanger 1 antibody (ab58304) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human stomach.

Anti-Sodium / Hydrogen Exchanger 1 antibody [4E9] - ab24018 from Abcam

Prices $373.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4E9

Anti-Sodium / Hydrogen Exchanger 1 antibody [EPR6975] - ab126725 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6975
All lanes : Anti-Sodium / Hydrogen Exchanger 1 antibody [EPR6975] (ab126725) at 1/1000 dilutionLane 1 : MOLT4 cell lysateLane 2 : Caco 2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SLC9A1 / NHE1 Antibody (C-Terminus) - LS-C16748 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SLC9A1 / NHE1 Antibody (C-Terminus) - LS-C16749 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1 / NHE1 Antibody (C-Terminus) - LS-C16750 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Chicken
Clonality Polyclonal

Anti-SLC9A1 / NHE1 Antibody (C-Terminus) - LS-C16751 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-SLC9A1 / NHE1 Antibody (C-Terminus) - LS-C16752 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1 / NHE1 Antibody (C-Terminus) - LS-C45619 from LifeSpan Bioscience

Prices $625.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-SLC9A1 / NHE1 Antibody (Cytoplasmic Domain) - LS-C94851 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC9A1 / NHE1 Antibody (aa31-130, Azide-free) - LS-C330665 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-SLC9A1 / NHE1 Antibody (C-Terminus) - LS-C110827 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SLC9A1 antibody LS-C110827 Western blot of PANC1 cell lysate.

Anti-SLC9A1 / NHE1 Antibody (clone 2F5) - LS-C133438 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F5
Detection limit for recombinant GST tagged SLC9A1 is approximately 0.3 ng/ml as a capture antibody.

Anti-SLC9A1 / NHE1 Antibody (Extracellular Domain, clone EPR6975) - LS-C152366 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6975
Western blot analysis on (A) Molt-4 and (B) Caco-2 cell lysates using anti-SLC9A1 antibody.

Anti-SLC9A1 / NHE1 Antibody - LS-C140588 from LifeSpan Bioscience

Prices $460.00
Sizes 10 blot
Host Rabbit
Clonality Polyclonal
Western blot of NHE1 antibody (LS-C140588) on HT-29 cell lysate. Lysate used at 30 ug/ml. Antibody used at 1:400 dilution. Secondary antibody, mouse anti-rabbit HRP, used at 1:50k dilution.
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