| Gene Symbol |
NOS2
|
| Entrez Gene |
4843
|
| Alt Symbol |
HEP-NOS, INOS, NOS, NOS2A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nitric oxide synthase 2, inducible
|
| Other Description |
NOS type II|NOS, type II|hepatocyte NOS|inducible NO synthase|inducible NOS|nitric oxide synthase 2A (inducible, hepatocytes)|nitric oxide synthase, inducible|nitric oxide synthase, macrophage|peptidyl-cysteine S-nitrosylase NOS2
|
| Swissprots |
A1L3U5 Q4TTS5 O94994 P35228 Q16263 O60757 B7ZLY2 Q16692 Q9UD42
|
| Accessions |
AAY43131 ABY87543 CAA02473 EAW51048 EAW51049 EAW51050 P35228 AB022318 BAA37123 AF068236 AAC19133 AK304252 BAG65119 BC130283 AAI30284 BC144126 AAI44127 D26525 BAA05531 HQ258688 ADR83439 L09210 AAA59171 L24553 AAA36375 S75615 AAD14179 S76479 AAD14226 U05810 AAA56666 U20141 AAB60366 U31511 AAB49041 X73029 CAA51512 XM_011524859 XP_011523161 XM_011524860 XP_011523162 XM_011524861 XP_011523163 XM_011524862 XP_011523164 NM_000625 NP_000616 NM_153292
|
| Function |
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
|
| Tissue Specificity |
Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
|
| Top Pathways |
Tuberculosis, Chagas disease (American trypanosomiasis), Salmonella infection, Pertussis, Toxoplasmosis
|