NOS2

Gene Symbol NOS2
Entrez Gene 4843
Alt Symbol HEP-NOS, INOS, NOS, NOS2A
Species Human
Gene Type protein-coding
Description nitric oxide synthase 2, inducible
Other Description NOS type II|NOS, type II|hepatocyte NOS|inducible NO synthase|inducible NOS|nitric oxide synthase 2A (inducible, hepatocytes)|nitric oxide synthase, inducible|nitric oxide synthase, macrophage|peptidyl-cysteine S-nitrosylase NOS2
Swissprots A1L3U5 Q4TTS5 O94994 P35228 Q16263 O60757 B7ZLY2 Q16692 Q9UD42
Accessions AAY43131 ABY87543 CAA02473 EAW51048 EAW51049 EAW51050 P35228 AB022318 BAA37123 AF068236 AAC19133 AK304252 BAG65119 BC130283 AAI30284 BC144126 AAI44127 D26525 BAA05531 HQ258688 ADR83439 L09210 AAA59171 L24553 AAA36375 S75615 AAD14179 S76479 AAD14226 U05810 AAA56666 U20141 AAB60366 U31511 AAB49041 X73029 CAA51512 XM_011524859 XP_011523161 XM_011524860 XP_011523162 XM_011524861 XP_011523163 XM_011524862 XP_011523164 NM_000625 NP_000616 NM_153292
Function Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Tissue Specificity Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets.
Top Pathways Tuberculosis, Chagas disease (American trypanosomiasis), Salmonella infection, Pertussis, Toxoplasmosis

NOS (C-12) - sc-49055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NOS2 (C-11) - sc-7271 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NOS2 (C-11): sc-7271. Western blot analysis of NOS2 expression in LPS and IFN-γ-treated RAW 264.7 whole cell lysate.

NOS2 (C-19) - sc-649 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NOS2 (C-19): sc-649. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

NOS2 (H-174) - sc-8310 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NOS2 (H-174): sc-8310. Western blot analysis of NOS2 expression in RAW 264.7 (A) and LPS/PMA-treated RAW 264.7 (B) whole cell lysates.

NOS2 (N-20) - sc-651 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NOS2 (N-20) PE: sc-651 PE. Intracellular FCM analysis of fixed and permeabilized untreated (green line histogram) and LPS/PMA-treated (solid orange histogram) RAW 264.7 cells. Dotted pink histogram represents the isotype control, normal rabbit IgG: sc-3871.

Anti-iNOS (phospho Y151) antibody - ab95866 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab95866 at 1/100 dilution staining iNOS in human colon carcinoma tissue sections by Immunohistochemistry (Formalin/ PFA-fixed paraffin-embedded tissue sections). Left image shows staining with ab95866 whilst right one shows staining with primary antibody incubated with peptide before detection.

Anti-iNOS (phospho Y151) antibody - ab182640 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-iNOS (phospho Y151) antibody (ab182640) at 1/500 dilutionLane 1 : Rat kidney lysateLane 2 : Rat kidney lysate with immunizing peptide

Anti-iNOS (phospho Y151) antibody - ab193371 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human colon carcinoma tissue labelling iNOS with ab193371 at a 1/50 dilution. Right panel was preincubated with blocking peptide.

Anti-iNOS antibody - ab3523 from Abcam

Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of iNOS in NIH-3T3 Cells (ab7179). Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a iNOS polyclonal antibody (ab3523) at a dilution of 1:20 overnight at 4 C and incubated with a DyLight-488 conjugated secondary antibody. iNOS staining (green) F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Images were taken at 60X magnification.

Anti-iNOS antibody - ab95441 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human intestinal cancer tissue labelling iNOS with ab95441 at 1µg/ml.

Anti-iNOS antibody - ab21775 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-iNOS antibody (ab21775) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ugLane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ug SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilutionPerformed under reducing conditions.

Anti-iNOS antibody - ab53769 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-iNOS antibody (ab53769) at 1/500 dilutionLane 1 : Extracts from NIH/3T3 cellsLane 2 : Extracts from NIH/3T3 cells, plus peptide

Anti-iNOS antibody - ab204017 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-iNOS antibody (ab204017)Lane 1 : Rat brain tissue lysate at 50 µgLane 2 : Mouse brain tissue lysate at 50 µgLane 3 : Rat PC12 whole cell lysate at 40 µgLane 4 : Rat NRK whole cell lysate at 40 µgLane 5 : HeLa whole cell lysate at 40 µgLane 6 : Human placenta tissue lysate at 50 µgLane 7 : HT1080 whole cell lysate at 40 µgLane 8 : MM1231 whole cell lysate at 40 µg

Anti-iNOS antibody - ab79342 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-iNOS antibody (ab79342) at 1/500 dilutionLane 1 : extracts from 3T3 cells Lane 2 : extracts from 3T3 cells with immunizing peptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-iNOS antibody [2G4] - ab195661 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2G4
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human skeletal muscle sections labeling iNOS with ab195661 at 10 µg/mL.

Anti-iNOS antibody [4E5] - ab129372 from Abcam

Prices $390.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E5
ab129372 at 1/200 dilution staining iNOS in paraffin embedded liver cancer tissue by imunohistochemistry, with DAB staining.

Anti-iNOS antibody [EP16634] - ab202417 from Abcam

Prices $347.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP16634
All lanes : Anti-iNOS antibody [EP16634] (ab202417) at 1/10000 dilutionLane 1 : Untreated RAW 264.7 (Mouse macrophage cells transformed with Abelson murine leukemia virus) whole cell lysateLane 2 : RAW 264.7 (Mouse macrophage cells transformed with Abelson murine leukemia virus) treated with 0.1 mg/ml LPS for 6 hours whole cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-iNOS antibody [EPR16635] - ab178945 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR16635
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized RAW 264.7 (Mouse macrophage cells transformed with Abelson murine leukemia virus) cells treated with LPS (0.1mg/ml), for 6 hours labeling iNOS with ab178945 at 1/500 dilution, followed by Goat anti-rabbit IgG (Alexa Fluor® 488) (ab150077) secondary antibody at 1/500 dilution (green).Confocal image showing cytoplasmic staining on RAW 264.7 cells, treated with LPS (0.1mg/ml), for 6 hours.The nuclear counterstain is DAPI (blue).Tubulin is detected with ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution and ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution (red).The negative controls are as follows:--ve control 1: ab178945 at 1/500 dilution followed by ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution.-ve control 2: ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution followed by ab150077 (Alexa Fluor®488 Goat Anti-Rabbit IgG H&L) at 1/500 dilution.

Anti-iNOS antibody [K13-A] - ab136918 from Abcam

Prices $378.00
Sizes 250 µl
Host Rabbit
Clonality Monoclonal
Clone K13-A
ab136918 staining iNOS in human blood vessel tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde, permeabilized with saponine and blocked with 1% BSA + 5% NGS in PBS for 30 minutes at 20°C; antigen retrieval was by heat mediation in EDTA. Samples were incubated with primary antibody (1/1000 in PBS + 1% BSA) for 9 hours at 4°C. A Biotin-conjugated goat anti-rabbit IgG polyclonal (1/400) was used as the secondary antibody.See Abreview

Anti-iNOS antibody, prediluted - ab15326 from Abcam

Prices $382.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
Human lung stained with ab15326 in IHC paraffin fixed sections.

Anti-NOS2 / iNOS Antibody (aa1131-1144) - LS-C15856 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NOS2 / iNOS Antibody (aa17-31) - LS-C15855 from LifeSpan Bioscience

Prices $665.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NOS2 / iNOS Antibody (C-Terminus) - LS-C15859 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NOS2 / iNOS Antibody (C-Terminus) - LS-C15860 from LifeSpan Bioscience

Prices $455.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-NOS2 / iNOS Antibody (aa1131-1144) - LS-C15863 from LifeSpan Bioscience

Prices $375.00
Sizes 25 µl
Host Rabbit
Clonality Polyclonal
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