Gene Symbol | ORMDL3 |
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Entrez Gene | 94103 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | ORMDL sphingolipid biosynthesis regulator 3 |
Other Description | ORM1-like protein 3 |
Swissprots | Q6UY83 Q8N138 B3KS83 |
Accessions | CAC24860 CAF85976 CAF86524 CAK32168 EAW60616 EAW60617 EAW60618 EAW60619 EAW60620 Q8N138 AF151043 AAF36129 AF373101 AAN76521 AF373102 AAN76522 AF395708 AAM43507 AK074811 BAC11223 AK075212 BAC11476 AK093063 BAG52645 AX775843 CAE11621 AY357943 AAQ57273 BC000638 BC017087 AAH17087 BC018837 BC050710 BC054042 BC071833 AAH71833 DB127807 HQ447484 ADQ31970 XM_005257825 XP_005257882 XM_005257827 XP_005257884 NM_139280 NP_644809 |
Function | Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. {ECO:0000269|PubMed:20182505}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12093374, ECO:0000269|PubMed:19819884}; Multi- pass membrane protein {ECO:0000269|PubMed:12093374, ECO:0000269|PubMed:19819884}. |
Tissue Specificity | Widely expressed. Expressed in adult and fetal heart, brain, lung, liver, skeletal muscle and kidney. Expressed in adult pancreas and placenta and in fetal spleen abd thymus. {ECO:0000269|PubMed:12093374}. |
ORMDL3 CRISPR/Cas9 KO Plasmid (h) - sc-403587 from Santa Cruz Biotechnology
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ORMDL3 HDR Plasmid (h) - sc-403587-HDR from Santa Cruz Biotechnology
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ORMDL3 Double Nickase Plasmid (h) - sc-403587-NIC from Santa Cruz Biotechnology
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ORMDL3 Double Nickase Plasmid (h2) - sc-403587-NIC-2 from Santa Cruz Biotechnology
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ORMDL3 CRISPR Activation Plasmid (h) - sc-403587-ACT from Santa Cruz Biotechnology
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ORMDL3 CRISPR Activation Plasmid (h2) - sc-403587-ACT-2 from Santa Cruz Biotechnology
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ORMDL3 Lentiviral Activation Particles (h) - sc-403587-LAC from Santa Cruz Biotechnology
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ORMDL3 Lentiviral Activation Particles (h2) - sc-403587-LAC-2 from Santa Cruz Biotechnology
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ORMDL3 siRNA (h) - sc-93675 from Santa Cruz Biotechnology
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ORMDL3 shRNA Plasmid (h) - sc-93675-SH from Santa Cruz Biotechnology
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ORMDL3 shRNA (h) Lentiviral Particles - sc-93675-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU026451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16153 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16153 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09360 from Sigma-Aldrich
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ORMDL3 siRNA (Human) - CRJ4250 from Cohesion Biosciences
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shRNA set against Human ORMDL3 (NM_139280.2) - SHH368548 from Creative biogene
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Human ORMDL3 siRNA - orb274751 from Biorbyt
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ORMDL3 shRNA Plasmid (Human) - CHJ4250 from Cohesion Biosciences
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ORMDL3 miRNA 3'UTR clone - MiUTR3H-11013 from Creative biogene
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