| Gene Symbol | EPHA1 |
|---|---|
| Entrez Gene | 2041 |
| Alt Symbol | EPH, EPHT, EPHT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor A1 |
| Other Description | eph tyrosine kinase 1|ephrin type-A receptor 1|erythropoietin-producing hepatoma amplified sequence|erythropoietin-producing hepatoma receptor|hEpha1|oncogene EPH|soluble EPHA1 variant 1|soluble EPHA1 variant 2|tyrosine-protein kinase receptor EPH |
| Swissprots | Q15405 B5A966 B5A967 A1L3V3 P21709 |
| Accessions | AAD43440 AAS07458 CCQ43308 EAL23789 EAW51845 EAW51846 EAW51847 P21709 AA723562 AA723620 AA788809 AI057542 AK290351 BAF83040 AK313263 AU131228 BC130291 AAI30292 BC144156 CD653381 CN289899 CN289901 EU826604 ACF47640 EU826605 ACF47641 M18391 AAA36747 Z27409 CAA81796 XM_006715880 XP_006715943 XM_011515878 XP_011514180 XR_428169 NM_005232 NP_005223 |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}. |
| Tissue Specificity | Overexpressed in several carcinomas. |
| Top Pathways | Axon guidance |