| Gene Symbol |
IGF1
|
| Entrez Gene |
610255
|
| Alt Symbol |
IGF-I, IGFI, IGFIA
|
| Species |
Dog
|
| Gene Type |
protein-coding
|
| Description |
insulin-like growth factor 1 (somatomedin C)
|
| Other Description |
Insulin-like growth factor I|somatomedin C
|
| Swissprots |
P33712
|
| Accessions |
P33712 L08254 XM_848024 XP_853117 XM_861842 XP_866935
|
| Function |
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Progesterone-mediated oocyte maturation, p53 signaling pathway, Proteoglycans in cancer, Focal adhesion, Rap1 signaling pathway
|