| Gene Symbol | IGF1 |
|---|---|
| Entrez Gene | 610255 |
| Alt Symbol | IGF-I, IGFI, IGFIA |
| Species | Dog |
| Gene Type | protein-coding |
| Description | insulin-like growth factor 1 (somatomedin C) |
| Other Description | Insulin-like growth factor I|somatomedin C |
| Swissprots | P33712 |
| Accessions | P33712 L08254 XM_848024 XP_853117 XM_861842 XP_866935 |
| Function | The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Top Pathways | Progesterone-mediated oocyte maturation, p53 signaling pathway, Proteoglycans in cancer, Focal adhesion, Rap1 signaling pathway |