| Gene Symbol |
BCL2
|
| Entrez Gene |
403416
|
| Alt Symbol |
BCL-2
|
| Species |
Dog
|
| Gene Type |
protein-coding
|
| Description |
B-cell CLL/lymphoma 2
|
| Other Description |
apoptosis regulator Bcl-2
|
| Swissprots |
Q6R755
|
| Accessions |
Q6R755 AB116145 BAC81344 AB154172 BAD05044 AY509563 AAR92491 NM_001002949 NP_001002949
|
| Function |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
|
| Top Pathways |
Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway
|
