| Gene Symbol | BCL2 |
|---|---|
| Entrez Gene | 403416 |
| Alt Symbol | BCL-2 |
| Species | Dog |
| Gene Type | protein-coding |
| Description | B-cell CLL/lymphoma 2 |
| Other Description | apoptosis regulator Bcl-2 |
| Swissprots | Q6R755 |
| Accessions | Q6R755 AB116145 BAC81344 AB154172 BAD05044 AY509563 AAR92491 NM_001002949 NP_001002949 |
| Function | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| Top Pathways | Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway |
Apoptosis regulator Bcl-2, BCL2, Dog, ELISA Kit - E0778d from ARP American Research Products
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Canine BCL-2 ELISA Kit - CB0040 from NeoScientific
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Bcl2/AdenoVirus E1B 19kDa Interacting Protein 3, ELISA Kit - MBS085987 from MyBioSource
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B-cell CLL/lymphoma 2 - MBS9310640 from MyBioSource
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Canine Beta Cell Leukemia/Lymphoma 2 ELISA - E08B0033 from BlueGene Biotech
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Canine BCL2 ELISA Kit - E076493 from Biobool
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Canine BCL-2 ELISA Kit - ECB0040 from ABclonal
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BCL-2, ELISA Kit - MBS2607814 from MyBioSource
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Apoptosis regulator Bcl-2, ELISA Kit - MBS2884127 from MyBioSource
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Bcl2 (Apoptosis regulator Bcl-2), ELISA Kit - MBS7606735 from MyBioSource
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