| Gene Symbol |
SGK1
|
| Entrez Gene |
6446
|
| Alt Symbol |
SGK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
serum/glucocorticoid regulated kinase 1
|
| Other Description |
Sgk1 variant i3|serine/threonine protein kinase SGK|serine/threonine-protein kinase Sgk1|serum/glucocorticoid-regulated kinase 1
|
| Swissprots |
E1P583 B7Z5B2 B7UUP8 Q5TCN3 Q5TCN4 B7UUP7 O00141 Q5TCN2 Q9UN56 Q5VY65 B7UUP9
|
| Accessions |
AAN40971 CAA04146 EAW47991 EAW47992 EAW47993 O00141 AF153609 AAD41091 AK055077 BAG51463 AK098509 AK293383 BAH11497 AK295422 BAH12061 AK298688 BAH12848 BC001263 AAH01263 BC013832 BP384292 BQ183142 BX537882 CAD97879 BX649005 CAH10381 DA309338 DB450096 DC428953 EU518415 ACD35864 FM205707 CAR58095 FM205708 CAR58096 FM205709 CAR58097 FM205710 CAR58098 JQ836654 AFJ04414 Y10032 CAA71138 XM_011536071 XP_011534373 NM_001143676 NP_001137148 NM_001143677 NP_001137149 NM_001143678 NP_001137150 NM_001291995 NP_001278924 NM_005627 NP_005618
|
| Function |
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creat
|
| Subcellular Location |
Cytoplasm. Nucleus. Endoplasmic reticulum membrane. Cell membrane. Mitochondrion. Note=The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor- stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation.
|
| Tissue Specificity |
Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle. {ECO:0000269|PubMed:10548550, ECO:0000269|PubMed:18753299}.
|
| Top Pathways |
Aldosterone-regulated sodium reabsorption, PI3K-Akt signaling pathway
|