| Gene Symbol | Ccl5 |
|---|---|
| Entrez Gene | 81780 |
| Alt Symbol | Rantes, Scya5 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | chemokine (C-C motif) ligand 5 |
| Other Description | C-C motif chemokine 5|SIS-delta|T-cell-specific protein RANTES|regulated upon activation normal T-cell expressed and secreted|small inducible cytokine A5|small-inducible cytokine A5 |
| Swissprots | P50231 |
| Accessions | EDM05488 P50231 BC058138 AAH58138 BP467039 EF121972 ABL63411 EF122007 ABL63446 U06436 AAA96499 NM_031116 NP_112378 |
| Function | Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. {ECO:0000250|UniProtKB:P13501}. |
| Subcellular Location | Secreted. |
| Top Pathways | Chemokine signaling pathway, TNF signaling pathway, Herpes simplex infection, Influenza A, Rheumatoid arthritis |