Gene Symbol | CAPZB |
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Entrez Gene | 832 |
Alt Symbol | CAPB, CAPPB, CAPZ |
Species | Human |
Gene Type | protein-coding |
Description | capping protein (actin filament) muscle Z-line, beta |
Other Description | F-actin-capping protein subunit beta|capZ beta |
Swissprots | Q8TB49 Q5U0L4 Q32Q68 P47756 Q9NUC4 |
Accessions | EAW94888 EAW94889 EAW94890 EAW94891 P47756 AI799520 AK022336 AK125085 BAG54137 AK126650 AK301442 BAG62968 AK313113 BAG35935 BC008095 AAH08095 BC012305 BC024601 AAH24601 BC069031 BC107752 AAI07753 BC109241 AAI09242 BC109242 AAI09243 BE870234 BQ009850 BQ773230 BT019470 AAV38277 BT019471 AAV38278 BX647941 CB267021 CN273493 EB387955 HY021163 U03271 AAA87395 XM_006710938 XP_006711001 XM_011542228 XP_011540530 XM_011542229 XP_011540531 XM_011542230 XP_011540532 NM_001206540 NP_001193469 NM_001206541 NP_001193470 NM_001282162 NP_001269091 NM_004930 NP_004921 |
Function | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. |
CapZ-β siRNA (h) - sc-43661 from Santa Cruz Biotechnology
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CapZ-β shRNA Plasmid (h) - sc-43661-SH from Santa Cruz Biotechnology
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CapZ-β shRNA (h) Lentiviral Particles - sc-43661-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU087941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5360 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5360 from Sigma-Aldrich
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CAPZB siRNA (Human) - CRH0586 from Cohesion Biosciences
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CAPZB RNAi - H00000832-R01 from Novus Biologicals
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CAPZB - MBS8223024 from MyBioSource
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shRNA set against Human CAPZB (NM_004930.3) - SHH254533 from Creative biogene
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Human CAPZB siRNA - orb261088 from Biorbyt
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CAPZB shRNA Plasmid (Human) - CHH0586 from Cohesion Biosciences
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CAPZB miRNA 3'UTR clone - MiUTR3H-04219 from Creative biogene
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