KHSRP

Gene Symbol KHSRP
Entrez Gene 374140
Alt Symbol -
Species Chicken
Gene Type protein-coding
Description KH-type splicing regulatory protein
Other Description FUSE-binding protein 2|KH type-splicing regulatory protein|KH-type splicing regulatory protein (FUSE binding protein 2)|KSRP|far upstream element-binding protein 2|zipcode-binding protein 2
Swissprots Q8UVD9
Accessions Q8UVD9 AF461020 AAL66365 NM_204277 NP_989608
Function Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Binds to a 54-nucleotide localization signal (the 'zipcode') found in the 3'-UTR of beta-actin mRNA and may play a role in its localization. {ECO:0000250, ECO:0000269|PubMed:11781334}.
Subcellular Location Nucleus {ECO:0000269|PubMed:11781334}. Cytoplasm {ECO:0000269|PubMed:11781334}. Note=Predominantly nuclear.

Chicken KHSRP ORF Clone (NM_204277) - CDCB166268 from Creative biogene

Species Chicken
Accession Q8UVD9
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