| Gene Symbol |
KHSRP
|
| Entrez Gene |
374140
|
| Alt Symbol |
-
|
| Species |
Chicken
|
| Gene Type |
protein-coding
|
| Description |
KH-type splicing regulatory protein
|
| Other Description |
FUSE-binding protein 2|KH type-splicing regulatory protein|KH-type splicing regulatory protein (FUSE binding protein 2)|KSRP|far upstream element-binding protein 2|zipcode-binding protein 2
|
| Swissprots |
Q8UVD9
|
| Accessions |
Q8UVD9 AF461020 AAL66365 NM_204277 NP_989608
|
| Function |
Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Binds to a 54-nucleotide localization signal (the 'zipcode') found in the 3'-UTR of beta-actin mRNA and may play a role in its localization. {ECO:0000250, ECO:0000269|PubMed:11781334}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11781334}. Cytoplasm {ECO:0000269|PubMed:11781334}. Note=Predominantly nuclear.
|