| Gene Symbol |
GAPDH
|
| Entrez Gene |
493876
|
| Alt Symbol |
-
|
| Species |
Cat
|
| Gene Type |
protein-coding
|
| Description |
glyceraldehyde-3-phosphate dehydrogenase
|
| Other Description |
peptidyl-cysteine S-nitrosylase GAPDH
|
| Swissprots |
Q9N2D5
|
| Accessions |
Q9N2D5 AB038241 BAA90818 AF054608 AAC15981 AF097177 AAC72840 DQ403061 ABD77194 XM_006933438 XP_006933500 NM_001009307 NP_001009307
|
| Function |
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in infl
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. {ECO:0000250}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Alzheimer's disease, Biosynthesis of amino acids, Carbon metabolism
|