| Gene Symbol |
OSMR
|
| Entrez Gene |
9180
|
| Alt Symbol |
OSMRB, PLCA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
oncostatin M receptor
|
| Other Description |
IL-31 receptor subunit beta|IL-31R subunit beta|IL-31R-beta|IL-31RB|interleukin-31 receptor subunit beta|oncostatin-M specific receptor beta subunit|oncostatin-M-specific receptor subunit beta
|
| Swissprots |
Q6P4E8 Q99650 Q96QJ6
|
| Accessions |
CAL44879 CAL44943 CAL44954 CAP40197 CAV32861 CAX21680 CAX87006 CBL94055 CBX32719 CDM63726 EAW55976 EAW55977 Q99650 AI417125 AK304016 BAG64931 BC010943 AAH10943 BC063468 AAH63468 BC125209 AAI25210 BC125210 AAI25211 BP352496 BU619548 CA439576 CB265977 DR006275 U60805 AAC50946 XM_005248384 XP_005248441 XM_005248385 XP_005248442 XM_005248386 XP_005248443 XM_005248387 XP_005248444 XM_011514161 XP_011512463 XR_925661 NM_001168355 NP_001161827 NM_003999 NP_003990
|
| Function |
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. {ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:8999038}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines. {ECO:0000269|PubMed:8999038}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, PI3K-Akt signaling pathway
|
